{"id":"W2005199266","doi":"10.1038/gt.2011.26","title":"A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; RNA interference; Transgene; Transgenesis; Promoter; Gene silencing; Cell biology; Viral vector; Genetics; Chromatin; RNA; Gene; Gene expression; Reproductive technology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003331463,0.0002377289,0.0001942049,0.0001306783,0.00007532374,0.00002209709,0.0002409149,0.0001586834,0.0001121816],"category_scores_gemma":[0.000001263707,0.000211308,0.0001027374,0.0001369352,0.0001099704,0.000006687801,0.00003662141,0.0001524836,0.00001301247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001752505,"about_ca_system_score_gemma":0.0001198897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004072623,"about_ca_topic_score_gemma":0.0007196123,"domain_scores_codex":[0.9984547,0.0002165893,0.0001957459,0.0005280253,0.0001830364,0.0004218305],"domain_scores_gemma":[0.9994866,0.000009632774,0.00004817427,0.0003300868,0.00003745432,0.00008807189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002775359,0.0001358971,0.0006323329,0.00001093382,0.00008027599,0.00000565491,0.0005016255,0.00001351784,0.9322814,0.000002388303,0.00002587292,0.06353475],"study_design_scores_gemma":[0.001197929,0.002467121,0.00314391,0.000008958958,0.000004711463,0.00001579479,0.00003635901,0.00001250396,0.9911903,0.000156452,0.001516399,0.0002495969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911519,0.007743547,0.0002844885,0.00006651876,0.0001128621,0.000404888,0.00001668694,0.00002104954,0.0001980359],"genre_scores_gemma":[0.9932494,0.004836241,0.0003413463,0.000146105,0.0001481899,0.0001005742,0.00001272464,0.00004733665,0.001118075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06328515,"threshold_uncertainty_score":0.8616889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02873394104538611,"score_gpt":0.2636224944813807,"score_spread":0.2348885534359946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}