{"id":"W2005199266","doi":"10.1038/gt.2011.26","title":"A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells","year":2011,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children’s Health Research Institute; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; RNA interference; Transgene; Transgenesis; Promoter; Gene silencing; Cell biology; Viral vector; Genetics; Chromatin; RNA; Gene; Gene expression; Reproductive technology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003523153,0.0005821846,0.0003093949,0.0004183285,0.0002534573,0.0005984243,0.0003792894,0.0004216535,0.001001689],"category_scores_gemma":[0.0002387925,0.0004412689,0.0004180936,0.0002910347,0.0003530131,0.0003374553,0.0003586258,0.001064679,0.0007378837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004290573,"about_ca_system_score_gemma":0.0007448678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000603404,"about_ca_topic_score_gemma":0.001197824,"domain_scores_codex":[0.9997149,0.00004099074,0.00003169791,0.00005802139,0.00009616023,0.00005820389],"domain_scores_gemma":[0.9996972,0.00005376036,0.0000891727,0.00004971062,0.00004208005,0.00006810927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005039349,0.00002087515,0.0000624615,0.00001780049,0.000002483932,0.00001366805,0.000006865358,0.00008390337,0.9982131,0.0003787235,0.00001576675,0.001134026],"study_design_scores_gemma":[0.0000208394,0.0001100371,0.0004883242,0.000006089255,0.00002242956,0.0001162119,0.000007690342,0.0008752721,0.9964861,0.00008418971,0.00177798,0.000004876517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9319099,0.001497343,0.06079173,0.0001732995,0.0001080694,0.0001331799,0.0004155611,0.0007559801,0.004214908],"genre_scores_gemma":[0.959928,0.001061315,0.03313855,0.00006994121,0.00003560072,0.0001306995,0.0006046725,0.0003127271,0.004718516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001689,"threshold_uncertainty_score":0.003350973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02873394104538611,"score_gpt":0.2636224944813807,"score_spread":0.2348885534359946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}