{"id":"W2005211970","doi":"10.1007/s11030-010-9273-2","title":"Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes","year":2010,"lang":"en","type":"article","venue":"Molecular Diversity","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Chemistry; Stereochemistry; Amide; Cytotoxicity; Cytotoxic T cell; Androstane; IC50; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001235245,0.0005346952,0.000338132,0.0005863067,0.0001495626,0.0002930178,0.0002953179,0.0002232386,0.003320158],"category_scores_gemma":[0.0001250596,0.0002713809,0.0002671179,0.0005603947,0.0001393549,0.0001742515,0.0002482926,0.000387732,0.0009483688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831608,"about_ca_system_score_gemma":0.0002679765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000477184,"about_ca_topic_score_gemma":0.001166967,"domain_scores_codex":[0.9998561,0.00002425511,0.00001033512,0.00002731849,0.00004003356,0.00004186895],"domain_scores_gemma":[0.9999198,0.00001369471,0.00001961529,0.00001049641,0.00001063869,0.0000257844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000314612,0.00006014125,0.0001493681,0.00005391747,0.00001383247,0.00009727615,0.000022116,0.0006561559,0.9915864,0.0001500743,0.00009955706,0.006796497],"study_design_scores_gemma":[0.00009048518,0.001120591,0.001528368,0.000009378605,0.00005202767,0.0003066167,0.00002476364,0.00055972,0.9906941,0.00007543957,0.005526253,0.00001227859],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806007,0.002203608,0.008275139,0.00012424,0.00006487408,0.0001702739,0.002059205,0.0004255299,0.006076442],"genre_scores_gemma":[0.9747961,0.002778052,0.006455048,0.0001364358,0.00003153825,0.0001505687,0.003398985,0.00009279028,0.01216053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003320158,"threshold_uncertainty_score":0.01110703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00783533812507521,"score_gpt":0.2096827497765298,"score_spread":0.2018474116514546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}