{"id":"W2005234239","doi":"10.1021/jo1003136","title":"Chemoenzymatic Synthesis of Amaryllidaceae Constituents and Biological Evaluation of their C-1 Analogues. The Next Generation Synthesis of 7-Deoxypancratistatin and <i>trans</i>-Dihydrolycoricidine","year":2010,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor; Brock University","funders":"National Center for Research Resources","keywords":"Amaryllidaceae Alkaloids; Aldehyde; Chemistry; Aziridine; Total synthesis; Stereochemistry; Hydroxymethyl; Organic chemistry; Catalysis; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001501063,0.0003271287,0.0002533829,0.000226664,0.0001810083,0.0001824588,0.0002392553,0.0002506812,0.001125244],"category_scores_gemma":[0.0001430337,0.0001102117,0.0001981604,0.0002827063,0.0001428549,0.0001965337,0.0002226676,0.0004352893,0.0005233722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002488358,"about_ca_system_score_gemma":0.0002135973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000573445,"about_ca_topic_score_gemma":0.001334274,"domain_scores_codex":[0.9998949,0.000017903,0.0000101326,0.00002475276,0.00003170066,0.00002058281],"domain_scores_gemma":[0.9999092,0.000009374729,0.00001780596,0.0000178028,0.00002530194,0.00002065571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003960092,0.00001805014,0.00006054803,0.0000724515,0.000004936183,0.00005119206,0.00001194025,0.0001188645,0.9948422,0.000134066,0.0000346472,0.004611515],"study_design_scores_gemma":[0.00002650177,0.0006953665,0.001652205,0.000008152502,0.00001723636,0.0003013615,0.0000111136,0.0002239009,0.9850661,0.00007992376,0.01191096,0.00000708245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447985,0.01381381,0.01752343,0.0002591434,0.0001690635,0.000438386,0.002141712,0.0002273953,0.02062858],"genre_scores_gemma":[0.971541,0.004982715,0.01670699,0.0001203781,0.00003748754,0.000129511,0.001623129,0.00003383966,0.004824962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001125244,"threshold_uncertainty_score":0.003764331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03541712395450958,"score_gpt":0.2388670337766616,"score_spread":0.2034499098221521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}