{"id":"W2005255483","doi":"10.1371/journal.pone.0012563","title":"Lovastatin Inhibits VEGFR and AKT Activation: Synergistic Cytotoxicity in Combination with VEGFR Inhibitors","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research; Ontario Institute for Cancer Research","keywords":"Protein kinase B; Autocrine signalling; Lovastatin; Cancer research; PI3K/AKT/mTOR pathway; EGFR inhibitors; Kinase insert domain receptor; Epidermal growth factor receptor; Angiogenesis; Biology; Chemistry; Cell biology; Signal transduction; Vascular endothelial growth factor A; Vascular endothelial growth factor; Receptor; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001299512,0.0001281025,0.0001627801,0.00005636402,0.00008024952,0.00004261768,0.00006137193,0.00012213,0.00001133985],"category_scores_gemma":[0.0001474165,0.000123289,0.00001777977,0.000122279,0.00009473583,0.00001099797,0.00004412475,0.0001784837,0.000003306178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001201989,"about_ca_system_score_gemma":0.0000709128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008335325,"about_ca_topic_score_gemma":0.0005893389,"domain_scores_codex":[0.9991842,0.00003040539,0.0001602271,0.0002774067,0.000177436,0.0001703445],"domain_scores_gemma":[0.9995491,0.00001782141,0.00007657645,0.0001934669,0.00009126065,0.00007179217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009719299,0.0004631174,0.005946374,0.00005311837,0.00003145544,1.490482e-7,0.00008407119,0.000004193374,0.9920375,0.0001792644,0.0003468004,0.0007568086],"study_design_scores_gemma":[0.00143842,0.000232144,0.01833624,0.00008933571,0.00002809488,0.000002548114,0.00004404249,0.00005373668,0.9766116,0.00009198488,0.002873079,0.000198737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998428,0.00009721602,0.0001625627,0.0001940424,0.000311352,0.0002454713,0.000008585466,0.00001305353,0.000539682],"genre_scores_gemma":[0.9965878,0.00006377857,0.0008879019,0.0001270183,0.001895121,0.00004468243,0.00006875274,0.00001992861,0.0003049949],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01542581,"threshold_uncertainty_score":0.502758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178831777422111,"score_gpt":0.2111074202727355,"score_spread":0.1993191024985143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}