{"id":"W2005255483","doi":"10.1371/journal.pone.0012563","title":"Lovastatin Inhibits VEGFR and AKT Activation: Synergistic Cytotoxicity in Combination with VEGFR Inhibitors","year":2010,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Cancer Institute; Canadian Institutes of Health Research; Ontario Institute for Cancer Research","keywords":"Protein kinase B; Autocrine signalling; Lovastatin; Cancer research; PI3K/AKT/mTOR pathway; EGFR inhibitors; Kinase insert domain receptor; Epidermal growth factor receptor; Angiogenesis; Biology; Chemistry; Cell biology; Signal transduction; Vascular endothelial growth factor A; Vascular endothelial growth factor; Receptor; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002239177,0.0004590485,0.0007486544,0.0004756759,0.0001554046,0.0004196411,0.0002423714,0.000264126,0.0007531584],"category_scores_gemma":[0.0001251599,0.0001338554,0.0004836865,0.0003400427,0.0001816372,0.0002169018,0.0002371909,0.0004993758,0.0003416937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003436528,"about_ca_system_score_gemma":0.0003063941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003510612,"about_ca_topic_score_gemma":0.001381817,"domain_scores_codex":[0.9997409,0.00006152596,0.0000360934,0.00003740628,0.00006140479,0.0000626968],"domain_scores_gemma":[0.999917,0.00001550558,0.00001930211,0.00001199515,0.000009489978,0.00002659668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001486678,0.0004849998,0.0008752472,0.0003520159,0.0001148875,0.0001862906,0.00003003688,0.0004122632,0.9721248,0.0002185491,0.0005356206,0.02317862],"study_design_scores_gemma":[0.0004262471,0.003920247,0.00460014,0.00002239575,0.0002190264,0.001165246,0.00002858637,0.00140878,0.9718926,0.0001220541,0.01617774,0.00001695609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9583535,0.02935901,0.004980347,0.0006666891,0.0002524965,0.0002118375,0.0005767997,0.0003015605,0.005297802],"genre_scores_gemma":[0.9868271,0.008508575,0.002542359,0.0001065038,0.00007689162,0.00006350673,0.000430927,0.00001767652,0.001426423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007531584,"threshold_uncertainty_score":0.002519608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178831777422111,"score_gpt":0.2111074202727355,"score_spread":0.1993191024985143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}