{"id":"W2005281315","doi":"10.1074/jbc.m112.414581","title":"Mouse Prion Protein Polymorphism Phe-108/Val-189 Affects the Kinetics of Fibril Formation and the Response to Seeding","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; University of Alberta","funders":"","keywords":"Fibril; PRNP; In vitro; Kinetics; Biophysics; Recombinant DNA; Chemistry; Prion protein; Biology; Allele; In vivo; Cell biology; Genetics; Biochemistry; Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001831824,0.0004094907,0.0001965657,0.0003014768,0.000108806,0.0002417213,0.0002193538,0.0004330026,0.001492538],"category_scores_gemma":[0.0002932492,0.0002259614,0.0002682439,0.0001361109,0.0002504462,0.0001510055,0.0001379407,0.0005818631,0.0004090158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001858159,"about_ca_system_score_gemma":0.00009868543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004116638,"about_ca_topic_score_gemma":0.0003871023,"domain_scores_codex":[0.9997424,0.00006731671,0.00003773799,0.00005015527,0.00005041139,0.00005193048],"domain_scores_gemma":[0.9994466,0.0001231109,0.0002003761,0.00004165986,0.00002596765,0.0001622221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004487401,0.00007779508,0.0005892519,0.00001669266,0.00001000371,0.00008975303,0.000008216598,0.00003629883,0.9982442,0.00002601617,0.00001949574,0.0004335595],"study_design_scores_gemma":[0.0001063683,0.002175675,0.05590067,0.00002157429,0.00008179907,0.001629546,0.00004150027,0.001379117,0.9373288,0.0001135741,0.001195722,0.00002565335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989084,0.0002496679,0.0003012271,0.0000259138,0.00001130902,0.00001231165,0.0001449356,0.00003454143,0.0003116795],"genre_scores_gemma":[0.9983633,0.0001931148,0.0005227368,0.00003537033,0.00000908082,0.00001850344,0.0001906652,0.00002891694,0.0006384112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001492538,"threshold_uncertainty_score":0.004993021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01092473807772566,"score_gpt":0.2305084559350245,"score_spread":0.2195837178572989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}