{"id":"W2005298758","doi":"10.1074/jbc.m114.599712","title":"Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":185,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"ARC Centre for Excellence in Convergent Bio-Nano Science and Technology; National Health and Medical Research Council; Bayerische Forschungsstiftung; Monash University","keywords":"Protease-activated receptor 2; Chemistry; Cell biology; Inflammation; Hyperalgesia; Adenylyl cyclase; Proteases; TRPV1; Receptor; Protease-activated receptor; Nociception; Transient receptor potential channel; Internal medicine; Biology; Thrombin; Biochemistry; Enzyme-linked receptor; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002306439,0.0005404323,0.0004940708,0.000318935,0.0001800694,0.0003093465,0.0002723485,0.0004955997,0.002052179],"category_scores_gemma":[0.0001955356,0.0002570417,0.0006643694,0.0002493259,0.0004657905,0.0002960017,0.0002740585,0.001050896,0.0002555714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004585961,"about_ca_system_score_gemma":0.0002877909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000571249,"about_ca_topic_score_gemma":0.0007488218,"domain_scores_codex":[0.9995549,0.00007412612,0.00004262762,0.00006779968,0.00007188929,0.0001886263],"domain_scores_gemma":[0.9998791,0.00001757139,0.00003935446,0.00001909875,0.000009060724,0.00003579981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007286011,0.00009248951,0.0001819288,0.00005678015,0.00001429595,0.0001241851,0.00001665466,0.00004950597,0.9975356,0.0001499459,0.00006453902,0.0009854997],"study_design_scores_gemma":[0.0001562459,0.003411994,0.005352806,0.0000108114,0.00004470437,0.0007406005,0.00005513103,0.0007783976,0.987785,0.0001113725,0.0015428,0.00001010825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957246,0.001201303,0.001245541,0.0001681526,0.00005077008,0.00005142191,0.0002768165,0.00009019364,0.001191223],"genre_scores_gemma":[0.9960723,0.0008495714,0.001042074,0.0001001125,0.00001797128,0.00007590352,0.0002824992,0.00001545921,0.001544217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002052179,"threshold_uncertainty_score":0.006865263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114398632497343,"score_gpt":0.2619690194630574,"score_spread":0.230825033138084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}