{"id":"W2005354461","doi":"10.1016/j.imbio.2012.02.009","title":"Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: A versatile platform for fine epitope mapping","year":2012,"lang":"en","type":"article","venue":"Immunobiology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Epitope; Monoclonal antibody; Immune system; Antibody; Epitope mapping; Biology; Cytokine; Computational biology; Mutagenesis; Antigen; Cell biology; Immunology; Genetics; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003404655,0.00030027,0.0001832669,0.0002895335,0.0001504065,0.0003499588,0.0003001779,0.0003781808,0.001266759],"category_scores_gemma":[0.0003001023,0.0001786387,0.0002325027,0.0001199279,0.0003836857,0.0004545596,0.0002222902,0.0009802795,0.0002200186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114724,"about_ca_system_score_gemma":0.0002147558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002918121,"about_ca_topic_score_gemma":0.0004426609,"domain_scores_codex":[0.9999272,0.00001639488,0.000004577211,0.00001354504,0.00001780188,0.00002056298],"domain_scores_gemma":[0.9998555,0.00006495532,0.00002202717,0.00002468903,0.00001629303,0.00001639092],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004805585,0.000008827025,0.00008573796,0.00002293302,0.000002448936,0.00002558431,0.000007026138,0.00008730568,0.9969406,0.0005846377,0.0000317347,0.002155108],"study_design_scores_gemma":[0.0000275099,0.000170446,0.002057065,0.000006585435,0.00001758355,0.0002108546,0.0000234077,0.001244918,0.9924684,0.0008909049,0.002876964,0.000005193505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9117219,0.01100027,0.07050666,0.0008899468,0.0001282715,0.00006441123,0.0002715784,0.0001756115,0.005241353],"genre_scores_gemma":[0.9718658,0.003812165,0.02214542,0.0002937774,0.00006795827,0.00004932668,0.0003184741,0.00003149864,0.00141556],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001266759,"threshold_uncertainty_score":0.004237711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03667554933955769,"score_gpt":0.3038947361995307,"score_spread":0.267219186859973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}