{"id":"W2005365429","doi":"10.1016/j.phrs.2014.06.002","title":"Oxygen glucose deprivation-induced astrocyte dysfunction provokes neuronal death through oxidative stress","year":2014,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"National Research Council Canada","funders":"Fondation pour la Recherche Médicale; Aix-Marseille Université; Fondation Motrice","keywords":"Astrocyte; Oxidative stress; Neurotoxicity; Neuroprotection; Glutamate receptor; Pharmacology; Glutathione; Biology; Astrogliosis; Reactive oxygen species; Ischemia; Cell biology; Excitotoxicity; Programmed cell death; Chemistry; Apoptosis; Endocrinology; Internal medicine; Medicine; Biochemistry; Central nervous system; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001015992,0.0002467096,0.0002206797,0.0001963863,0.0008485214,0.0002353569,0.0006043637,0.0001103284,0.001250889],"category_scores_gemma":[0.003823061,0.0002039102,0.00008478059,0.0007265162,0.0001491485,0.000578361,0.0003193858,0.0009487513,0.001020581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009282125,"about_ca_system_score_gemma":0.0001021227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001037081,"about_ca_topic_score_gemma":0.000003381789,"domain_scores_codex":[0.9940141,0.002411858,0.0004045796,0.0009753801,0.001458499,0.000735615],"domain_scores_gemma":[0.9972714,0.001733374,0.0001244871,0.0002921859,0.0003067902,0.0002717887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002343722,0.0002401683,0.00007337348,0.00001082547,0.00000437659,0.0000137896,0.00006368453,0.0002356148,0.9702913,0.02531653,0.0007465255,0.002769478],"study_design_scores_gemma":[0.0009548512,0.0006895234,0.001712107,0.000006201162,0.000008304491,0.000008360418,0.00001783057,0.01031535,0.9752954,0.003368396,0.00743844,0.0001852787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828423,0.000005368239,0.006448675,0.001589402,0.0004428285,0.0009456751,0.00001814355,0.0002536656,0.007453895],"genre_scores_gemma":[0.995741,0.00009047598,0.0004443167,0.00229615,0.0004263243,0.0002662367,0.00001565677,0.00003077339,0.0006890902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02194814,"threshold_uncertainty_score":0.9997572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2349312514349825,"score_gpt":0.4159143535215292,"score_spread":0.1809831020865467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}