{"id":"W2005507799","doi":"10.3747/co.20.1226","title":"Overall Survival Should Be the Primary Endpoint in Clinical Trials for Advanced Non-Small-Cell Lung Cancer","year":2013,"lang":"en","type":"article","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Health Sciences Centre; Mount Sinai Hospital; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Clinical endpoint; Surrogate endpoint; Oncology; Pemetrexed; Internal medicine; Lung cancer; Clinical trial; Progression-free survival; Cancer; Crizotinib; Chemotherapy; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001352348,0.0001739645,0.0008186048,0.00006124317,0.00006648876,0.00001395277,0.000121432,0.0001517517,0.0003283722],"category_scores_gemma":[0.0003999785,0.0001052918,0.0002745004,0.00008549034,0.00007612191,0.00006437657,0.00005413791,0.0003469795,0.00001224351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006055862,"about_ca_system_score_gemma":0.001018947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001738344,"about_ca_topic_score_gemma":0.0002511596,"domain_scores_codex":[0.9979764,0.0003274295,0.0008783982,0.0003410743,0.0001377115,0.0003389774],"domain_scores_gemma":[0.9973709,0.00178118,0.0002893743,0.0002664854,0.0001550716,0.0001370171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001573541,0.004349275,0.2334756,0.000684407,0.0005732694,0.00001672113,0.002030853,0.0001032104,0.001223142,0.0005808529,0.09475961,0.6606295],"study_design_scores_gemma":[0.0344751,0.00146743,0.3569109,0.000201917,0.001436161,0.00000463789,0.0004819443,0.001776203,0.0002357468,0.000405968,0.6023018,0.0003022495],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9468719,0.008050689,0.001406996,0.0221816,0.007450497,0.007594077,0.0001308023,0.00004526499,0.006268145],"genre_scores_gemma":[0.954682,0.00933047,0.003367679,0.009229166,0.003776045,0.01437259,0.0007199318,0.0001144185,0.004407678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6603273,"threshold_uncertainty_score":0.4293677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3022978229486874,"score_gpt":0.5550188770654189,"score_spread":0.2527210541167315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}