{"id":"W2005515451","doi":"10.1111/bjh.13094","title":"Phase <scp>II</scp> study of targeted therapy with temozolomide in acute myeloid leukaemia and high‐risk myelodysplastic syndrome patients pre‐screened for low O<sup>6</sup>‐methylguanine DNA methyltransferase expression","year":2014,"lang":"en","type":"article","venue":"British Journal of Haematology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; BC Cancer Agency; Juravinski Cancer Centre; Hôpital Maisonneuve-Rosemont; Princess Margaret Cancer Centre","funders":"Merck Canada; Merck","keywords":"Temozolomide; O-6-methylguanine-DNA methyltransferase; Myelodysplastic syndromes; Myeloid leukaemia; Medicine; Methyltransferase; Oncology; Decitabine; Cancer research; DNA methyltransferase; Internal medicine; DNA; DNA methylation; Glioblastoma; Methylation; Gene expression; Gene; Biology; Genetics; Bone marrow","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001253568,0.001297145,0.001746244,0.0004381557,0.0003365895,0.0006550952,0.0006918702,0.0009518185,0.002154432],"category_scores_gemma":[0.0006010368,0.0003956039,0.0008679107,0.0003764717,0.0006680176,0.0004107567,0.0003763727,0.00185882,0.0005311334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007353938,"about_ca_system_score_gemma":0.001608351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001356371,"about_ca_topic_score_gemma":0.002058674,"domain_scores_codex":[0.9995992,0.0002203729,0.00001679564,0.00004558795,0.00003098838,0.00008712256],"domain_scores_gemma":[0.9993508,0.0000768943,0.0001014531,0.0000531443,0.0000555725,0.0003620604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7026455,0.08582389,0.01550484,0.0005698105,0.0008771872,0.0004493299,0.0002999903,0.002781765,0.0936067,0.0003956116,0.004442174,0.09260321],"study_design_scores_gemma":[0.3380182,0.6224031,0.027316,0.00002690487,0.0002388888,0.0003841466,0.00004813898,0.001183686,0.007035395,0.0001641417,0.003161233,0.00002016515],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925015,0.001005639,0.0005315964,0.0002953329,0.00006265396,0.003556401,0.0006410212,0.00005873134,0.001346984],"genre_scores_gemma":[0.9863024,0.001066757,0.001887068,0.0008733092,0.000140367,0.003959717,0.003092998,0.00002193812,0.002655496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002154432,"threshold_uncertainty_score":0.007207334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008527743002371874,"score_gpt":0.2658117434983188,"score_spread":0.2572840004959469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}