{"id":"W2005542634","doi":"10.1016/j.cbi.2015.03.005","title":"Mitochondria and redox homoeostasis as chemotherapeutic targets of Araucaria angustifolia (Bert.) O. Kuntze in human larynx HEp-2 cancer cells","year":2015,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Reactive oxygen species; Apoptosis; Molecular biology; Superoxide dismutase; DNA damage; Cancer cell; Biology; Nitric oxide; Catalase; Biochemistry; DNA fragmentation; Chemistry; Antioxidant; Programmed cell death; Cancer; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007519684,0.0001574378,0.0002107217,0.0001934296,0.0001506148,0.0001862304,0.0001089045,0.0001531794,0.0008424951],"category_scores_gemma":[0.00004774566,0.00008569784,0.0001471441,0.0001489352,0.00009558868,0.000150206,0.0001071858,0.0002782442,0.0001478909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001563332,"about_ca_system_score_gemma":0.0001024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001388976,"about_ca_topic_score_gemma":0.002164824,"domain_scores_codex":[0.9999694,0.000006582379,0.000002226145,0.000007100693,0.000006070816,0.000008567945],"domain_scores_gemma":[0.9999785,0.000004739227,0.000004625948,0.000002936855,0.000004081076,0.000005043399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001605692,0.00002629132,0.0001769291,0.0000224085,0.000003256668,0.00002343334,0.00001452309,0.00003714434,0.9982617,0.0000747356,0.00002491461,0.001174116],"study_design_scores_gemma":[0.00002789294,0.0004250367,0.01155586,0.000005269314,0.00004009717,0.0001250234,0.00006479132,0.001057682,0.9842278,0.00008744398,0.002377773,0.000005235563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961777,0.002026198,0.0006393601,0.00009586314,0.00001461765,0.000007862121,0.0001334277,0.00004279099,0.0008622296],"genre_scores_gemma":[0.9976581,0.0005617891,0.0002788693,0.00002041109,0.000003107682,0.00000733294,0.0001423381,0.00000447641,0.001323435],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001388976,"threshold_uncertainty_score":0.002818406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648783772247049,"score_gpt":0.3240427673716482,"score_spread":0.2875549296491777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}