{"id":"W2005542634","doi":"10.1016/j.cbi.2015.03.005","title":"Mitochondria and redox homoeostasis as chemotherapeutic targets of Araucaria angustifolia (Bert.) O. Kuntze in human larynx HEp-2 cancer cells","year":2015,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Reactive oxygen species; Apoptosis; Molecular biology; Superoxide dismutase; DNA damage; Cancer cell; Biology; Nitric oxide; Catalase; Biochemistry; DNA fragmentation; Chemistry; Antioxidant; Programmed cell death; Cancer; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000102728,0.0002652539,0.0003574913,0.00006426922,0.00005596479,0.00002206982,0.0002483849,0.0002744131,0.0001469235],"category_scores_gemma":[0.0001433585,0.000237017,0.0001196964,0.0001149927,0.0002890668,0.00001209717,0.0001745529,0.0002652483,0.000009511541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006613467,"about_ca_system_score_gemma":0.00006049939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003022576,"about_ca_topic_score_gemma":0.0001211133,"domain_scores_codex":[0.9985765,0.0000625103,0.0003999386,0.0005501495,0.00008595065,0.0003249891],"domain_scores_gemma":[0.9991011,0.00004362186,0.0001825455,0.000333976,0.0001590763,0.0001796943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000147278,0.0002032074,0.004951358,0.00001817988,0.00008056007,0.000002336501,0.0001824426,0.00001246038,0.990597,0.00004745238,0.003442455,0.0003153294],"study_design_scores_gemma":[0.0007530485,0.0001767694,0.002212582,0.00003923409,0.00002784287,0.00001521716,0.0003636617,0.00001860267,0.9815066,0.0007629858,0.01384806,0.0002753853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948719,0.00196569,0.00006280181,0.0002817772,0.0002899326,0.000243229,0.0001184357,0.00001620881,0.002150004],"genre_scores_gemma":[0.9972975,0.0005446293,0.0005943054,0.0003532617,0.0002505177,0.00007904003,0.000228283,0.00002280207,0.000629714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01040561,"threshold_uncertainty_score":0.9665273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03648783772247049,"score_gpt":0.3240427673716482,"score_spread":0.2875549296491777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}