{"id":"W2005557489","doi":"10.1186/s13058-015-0522-2","title":"Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy","year":2015,"lang":"en","type":"review","venue":"Breast Cancer Research","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; Medisinske fakultet, Universitetet i Oslo; Institute of Biomedical Sciences, Academia Sinica; Biomedical Research Council; Deutsche Krebshilfe; Norges Forskningsråd; Universitetet i Oslo; Singapore Eye Research Institute; Stockholms Läns Landsting; Academia Sinica; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Medical Research Council; National Research Foundation of Korea; National Health and Medical Research Council; National Medical Research Council; Ministério da Ciência, Tecnologia e Inovação; U.S. Department of Health and Human Services; Haukeland Universitetssjukehus; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agency for Science, Technology and Research; Bundesministerium für Bildung und Forschung; Ministry of Education, Science and Technology; Ovarian Cancer Research Fund; Cancer Australia; National Research Foundation; National Institute for Health and Care Research; Canadian Institutes of Health Research; Cancerfonden; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; Akershus Universitetssykehus; Francis Crick Institute; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; Deutsches Krebsforschungszentrum; Universitetet i Bergen; Génome Québec; Kementerian Sains, Teknologi dan Inovasi; Susan G. Komen; Helsingin ja Uudenmaan Sairaanhoitopiiri; Taiwan Biobank; Itä-Suomen Yliopisto; European Commission; University of Cambridge; McGill University; Breast Cancer Research Foundation; National Breast Cancer Foundation; Universitetet i Tromsø; KWF Kankerbestrijding; Cancer Research UK","keywords":"Breast cancer; Oncology; Internal medicine; Hazard ratio; Medicine; Estrogen receptor; Chemotherapy; Single-nucleotide polymorphism; Proportional hazards model; Cancer; Surgical oncology; Confidence interval; Biology; Gene; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00120251,0.0004623538,0.001280005,0.0003415963,0.00005339503,0.00003804237,0.0006429008,0.0004386137,0.0002496479],"category_scores_gemma":[0.0001101961,0.0003742807,0.0002310239,0.0009389084,0.0002375311,0.00001432115,0.0002815926,0.0003781727,0.000001666471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007511655,"about_ca_system_score_gemma":0.005295192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002086917,"about_ca_topic_score_gemma":0.0004339245,"domain_scores_codex":[0.9956178,0.0010605,0.000787094,0.0008352601,0.001095116,0.00060425],"domain_scores_gemma":[0.996258,0.0001207104,0.000665695,0.0006242456,0.002116083,0.0002152994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.004322279,0.003171081,0.05174116,0.01658463,0.007184258,0.00003166995,0.001420944,0.0003469333,0.05337875,0.0000279284,0.00342526,0.8583651],"study_design_scores_gemma":[0.01065391,0.003323887,0.4920797,0.1441862,0.001946808,0.0001001053,0.000608851,0.00003195783,0.0573924,0.00006963933,0.2846726,0.004933891],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08975177,0.8924108,0.00001359452,0.0001946421,0.0001062337,0.003235455,0.01421862,0.00001352474,0.0000553365],"genre_scores_gemma":[0.1275406,0.8610747,0.0004935111,0.00004701916,0.0004486821,0.009075753,0.0008639917,0.0002118478,0.0002438745],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8534312,"threshold_uncertainty_score":0.9998709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05304220132767883,"score_gpt":0.4085496208114622,"score_spread":0.3555074194837834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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