{"id":"W2005557489","doi":"10.1186/s13058-015-0522-2","title":"Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with prognosis of estrogen receptor-negative breast cancer after chemotherapy","year":2015,"lang":"en","type":"review","venue":"Breast Cancer Research","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; Medisinske fakultet, Universitetet i Oslo; Institute of Biomedical Sciences, Academia Sinica; Biomedical Research Council; Deutsche Krebshilfe; Norges Forskningsråd; Universitetet i Oslo; Singapore Eye Research Institute; Stockholms Läns Landsting; Academia Sinica; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Medical Research Council; National Research Foundation of Korea; National Health and Medical Research Council; National Medical Research Council; Ministério da Ciência, Tecnologia e Inovação; U.S. Department of Health and Human Services; Haukeland Universitetssjukehus; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Agency for Science, Technology and Research; Bundesministerium für Bildung und Forschung; Ministry of Education, Science and Technology; Ovarian Cancer Research Fund; Cancer Australia; National Research Foundation; National Institute for Health and Care Research; Canadian Institutes of Health Research; Cancerfonden; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Breast Cancer Campaign; Akershus Universitetssykehus; Francis Crick Institute; National Institutes of Health; David F. and Margaret T. Grohne Family Foundation; Deutsches Krebsforschungszentrum; Universitetet i Bergen; Génome Québec; Kementerian Sains, Teknologi dan Inovasi; Susan G. Komen; Helsingin ja Uudenmaan Sairaanhoitopiiri; Taiwan Biobank; Itä-Suomen Yliopisto; European Commission; University of Cambridge; McGill University; Breast Cancer Research Foundation; National Breast Cancer Foundation; Universitetet i Tromsø; KWF Kankerbestrijding; Cancer Research UK","keywords":"Breast cancer; Oncology; Internal medicine; Hazard ratio; Medicine; Estrogen receptor; Chemotherapy; Single-nucleotide polymorphism; Proportional hazards model; Cancer; Surgical oncology; Confidence interval; Biology; Gene; Genotype; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001207955,0.0002305582,0.0002695033,0.0004445013,0.0001595977,0.000317307,0.0002373163,0.0003133179,0.001202735],"category_scores_gemma":[0.002083407,0.0001185628,0.000530235,0.0005623641,0.00021309,0.00009435287,0.0002111627,0.0002570557,0.0001009995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001311622,"about_ca_system_score_gemma":0.0001333276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009745377,"about_ca_topic_score_gemma":0.001018213,"domain_scores_codex":[0.9994487,0.0002300617,0.00005410895,0.0001436663,0.00008277663,0.00004069393],"domain_scores_gemma":[0.9980524,0.0006854385,0.0008432959,0.0002106378,0.00009748152,0.0001107978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001531379,0.00002506106,0.9871712,0.00002275603,0.0005009512,0.00009794103,0.00005152819,0.0001508495,0.007784105,0.00001414761,0.00003756991,0.002612491],"study_design_scores_gemma":[0.00003536047,0.0001868577,0.9978042,0.000005000223,0.0002836827,0.0002329011,0.00002133906,0.0002651102,0.001011273,0.00003113021,0.0001205325,0.000002655089],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9993073,0.0002757931,0.0001816462,0.00001391985,0.000002046676,0.000003121532,0.00009922634,0.000003235384,0.0001138215],"genre_scores_gemma":[0.9997309,0.00002554912,0.00008984744,0.000008582502,0.000003106411,0.000002997609,0.00008620626,0.000001580937,0.00005118991],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001207955,"threshold_uncertainty_score":0.006388366,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05304220132767883,"score_gpt":0.4085496208114622,"score_spread":0.3555074194837834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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