{"id":"W2005569083","doi":"10.1515/ejnm-2012-0010","title":"Limitations and niches of the active targeting approach for nanoparticle drug delivery","year":2012,"lang":"en","type":"article","venue":"European Journal of Nanomedicine","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; Ministero dello Sviluppo Economico; National Cancer Institute; Prostate Cancer Foundation; Ontario Institute for Cancer Research; Ontario Centres of Excellence; Ontario Ministry of Economic Development and Innovation","keywords":"Internalization; Biodistribution; Targeted drug delivery; Drug delivery; Drug; Nanoparticle; Nanomedicine; Blood circulation; Chemistry; Nanotechnology; Ligand (biochemistry); Cancer research; Biophysics; Pharmacology; Medicine; Biology; In vitro; Materials science; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007525165,0.0005059111,0.000602398,0.0008506865,0.0005960825,0.00251179,0.001590996,0.001714074,0.002554175],"category_scores_gemma":[0.004066204,0.0003518692,0.0004761265,0.0004805035,0.001899192,0.003367475,0.001461676,0.001549633,0.001056809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001153445,"about_ca_system_score_gemma":0.00124607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008449954,"about_ca_topic_score_gemma":0.0006597227,"domain_scores_codex":[0.9970957,0.001122003,0.0001835777,0.000404187,0.001062612,0.0001319494],"domain_scores_gemma":[0.9958306,0.002632965,0.0003946466,0.000319388,0.0006654333,0.0001571093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005667919,0.0003854676,0.002679,0.005723435,0.0001119144,0.0009601377,0.001607609,0.004122473,0.1959623,0.2638549,0.01028421,0.5137417],"study_design_scores_gemma":[0.0001393744,0.00216114,0.003424631,0.002194322,0.000206132,0.01043763,0.001461306,0.02716511,0.2088155,0.1408621,0.602882,0.0002507236],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1479951,0.4924302,0.2351944,0.05039574,0.00148915,0.0003198762,0.0002911872,0.0005574077,0.07132693],"genre_scores_gemma":[0.7552055,0.1442908,0.08027543,0.004445957,0.001166071,0.0006229232,0.0001965386,0.000217358,0.01357938],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007525165,"threshold_uncertainty_score":0.03979731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03865831180040626,"score_gpt":0.2324174176069601,"score_spread":0.1937591058065538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}