{"id":"W2005572129","doi":"10.1016/j.bpj.2013.11.663","title":"Crystal Structure of Cardiac Ryanodine Receptor N-Terminal Region Contains Unique Anion Binding Site Targeted by Disease-Associated Mutations","year":2014,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Ryanodine receptor 2; Ryanodine receptor; RYR1; Catecholaminergic polymorphic ventricular tachycardia; Chloride channel; Endoplasmic reticulum; Chemistry; Context (archaeology); Cardiac muscle; Biophysics; Mutant; Binding site; Cell biology; Biochemistry; Biology; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203056,0.0003710279,0.0005576733,0.0001223891,0.0004300638,0.0004253272,0.0006946297,0.0008013975,0.001443743],"category_scores_gemma":[0.0003011979,0.0001815275,0.0002658262,0.000229194,0.0003013349,0.0002488052,0.0002274668,0.001255165,0.0003162602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007825833,"about_ca_system_score_gemma":0.0005881125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004118246,"about_ca_topic_score_gemma":0.005124514,"domain_scores_codex":[0.9998778,0.00001414035,0.00001245111,0.00003015031,0.00004397798,0.00002150869],"domain_scores_gemma":[0.9998695,0.00002964079,0.00003360359,0.000005455471,0.00002334625,0.00003846049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002345857,0.0003569049,0.005441523,0.0004547915,0.0001700247,0.007782551,0.0004033178,0.005076877,0.95419,0.003808111,0.01107093,0.008899161],"study_design_scores_gemma":[0.004380454,0.001672637,0.1310542,0.0003243079,0.0008388946,0.03024144,0.001321416,0.09108195,0.6653152,0.003933162,0.06945816,0.000378325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987886,0.002495815,0.002222741,0.0009470159,0.0002843116,0.00003510429,0.002724887,0.0001774606,0.003226638],"genre_scores_gemma":[0.9882294,0.001034409,0.003130922,0.0003639487,0.00004466008,0.00002931,0.004510377,0.00003668299,0.002620378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004118246,"threshold_uncertainty_score":0.008188546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006453735706111401,"score_gpt":0.223313385978965,"score_spread":0.2168596502728536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}