{"id":"W2005675325","doi":"10.1016/j.mce.2010.01.014","title":"The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells","year":2010,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Nuclear Receptors and Signaling","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Natural Science Foundation of China","keywords":"Theca; Cholesterol side-chain cleavage enzyme; Steroidogenic acute regulatory protein; Orphan receptor; Gene knockdown; Internal medicine; Endocrinology; Biology; CYP17A1; Granulosa cell; Nuclear receptor; Cell biology; Transcription factor; Ovary; Messenger RNA; Cell culture; Medicine; Cytochrome P450; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001830448,0.0002271945,0.0003920173,0.0004624715,0.0005028752,0.0007171339,0.0002778857,0.000248352,0.002354037],"category_scores_gemma":[0.0003995603,0.0002409108,0.0003944904,0.0002683306,0.0004896543,0.0004667141,0.00043109,0.0005490562,0.0005467351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007950371,"about_ca_system_score_gemma":0.0006758625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004408441,"about_ca_topic_score_gemma":0.008349984,"domain_scores_codex":[0.9997365,0.00004060403,0.00001479022,0.0000633496,0.00004883686,0.00009593451],"domain_scores_gemma":[0.9998228,0.0000222477,0.00004176913,0.00002028421,0.0000404777,0.00005241721],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004799058,0.00001870004,0.002644862,0.00006618691,0.00001683534,0.0001267868,0.0001249416,0.00008709983,0.9908628,0.0006221804,0.0003239446,0.004625665],"study_design_scores_gemma":[0.000178544,0.0003900848,0.1403774,0.00007024377,0.0001180297,0.0009017957,0.001560842,0.002473035,0.8264878,0.001286304,0.02611109,0.00004490399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749312,0.01028672,0.004565414,0.0008248011,0.0002448626,0.00004348177,0.001132042,0.0001154651,0.007855944],"genre_scores_gemma":[0.9819081,0.002984021,0.001518256,0.0002036797,0.00006092318,0.00003557157,0.001127372,0.00007411887,0.01208802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004408441,"threshold_uncertainty_score":0.008765578,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008481996340600427,"score_gpt":0.2021983204900415,"score_spread":0.1937163241494411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}