{"id":"W2005676026","doi":"10.1038/sj.gt.3302578","title":"DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice","year":2005,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Nod; NOD mice; Autoimmunity; Biology; Immunology; CD40; DNA vaccination; CD28; Antigen presentation; Antigen; Antibody; Immune system; T cell; Diabetes mellitus; Cytotoxic T cell; Endocrinology; Immunization; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001019062,0.0001199643,0.0001162122,0.00006171541,0.00004607157,0.00003963428,0.00005707252,0.00007064464,0.0000084859],"category_scores_gemma":[0.00001066405,0.0001035701,0.000009861797,0.0001709365,0.00002265912,0.00001042772,0.00002087984,0.0000447662,0.000001826963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000819131,"about_ca_system_score_gemma":0.00002787275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000163889,"about_ca_topic_score_gemma":0.000113485,"domain_scores_codex":[0.9993777,0.00004103191,0.00009695957,0.000243036,0.00005181068,0.0001894432],"domain_scores_gemma":[0.9997634,0.00000449064,0.00004787169,0.00009458693,0.00003098719,0.00005869347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001057531,0.00005085807,0.03014746,0.000004068582,0.0000297494,3.059698e-7,0.0001121704,0.00001812969,0.9044504,0.000004555282,0.00001542261,0.06506119],"study_design_scores_gemma":[0.002535344,0.001851342,0.07980698,0.0000253093,0.000008569542,0.000002104857,0.0002326509,0.0002051604,0.9127065,0.00005542973,0.002205708,0.0003649138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968618,0.002596396,0.000006462572,0.0001714209,0.00001411297,0.0002849017,0.000008620517,0.000009810714,0.00004654834],"genre_scores_gemma":[0.997434,0.0005834164,0.001471273,0.0003421154,0.00004612043,0.00002358024,0.00004736967,0.00001844958,0.00003365263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06469628,"threshold_uncertainty_score":0.4223465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005225709731919416,"score_gpt":0.2209003222230195,"score_spread":0.2156746124911001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}