{"id":"W2005676026","doi":"10.1038/sj.gt.3302578","title":"DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice","year":2005,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Nod; NOD mice; Autoimmunity; Biology; Immunology; CD40; DNA vaccination; CD28; Antigen presentation; Antigen; Antibody; Immune system; T cell; Diabetes mellitus; Cytotoxic T cell; Endocrinology; Immunization; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004508514,0.001129152,0.0008330711,0.0009935673,0.0003018941,0.000532956,0.0006512098,0.001028708,0.001479777],"category_scores_gemma":[0.0002850835,0.0004203199,0.0005809242,0.0003190685,0.0006242266,0.0005102849,0.0002528512,0.002094052,0.0004979285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005662102,"about_ca_system_score_gemma":0.0004695654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008674345,"about_ca_topic_score_gemma":0.001086399,"domain_scores_codex":[0.9994772,0.00007491251,0.00004701022,0.0001397958,0.0001078656,0.0001531961],"domain_scores_gemma":[0.9995048,0.00007488565,0.0001749948,0.00005297501,0.00003156911,0.0001607028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008096794,0.0003933485,0.0002227544,0.0000472076,0.00001605989,0.00006768597,0.00002313481,0.0001422635,0.9963353,0.0001681385,0.00008064506,0.001693859],"study_design_scores_gemma":[0.0003196871,0.002434138,0.002398776,0.00002158819,0.00009079881,0.0003399549,0.00004316381,0.001532102,0.9905657,0.0001369698,0.00210281,0.00001431286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914476,0.0009610349,0.0037814,0.0003087564,0.0002324988,0.0000703519,0.0004005861,0.0004102903,0.002387551],"genre_scores_gemma":[0.9859061,0.001045629,0.003725349,0.000195094,0.0001103988,0.00011139,0.000601537,0.0001340542,0.008170498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001479777,"threshold_uncertainty_score":0.004950345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005225709731919416,"score_gpt":0.2209003222230195,"score_spread":0.2156746124911001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}