{"id":"W2005693512","doi":"10.1110/ps.9.2.332","title":"Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry","year":2000,"lang":"en","type":"article","venue":"Protein Science","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":244,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; Natural Sciences and Engineering Research Council of Canada; University of California, San Francisco; National Institute on Aging; National Institutes of Health","keywords":"Chemistry; Peptide; Electrospray ionization; Crystallography; Circular dichroism; Histidine; Cooperativity; Mass spectrometry; Divalent; Binding site; Cooperative binding; Stoichiometry; Ion; Dissociation constant; Biophysics; Biochemistry; Amino acid; Physical chemistry; Chromatography; Biology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002586332,0.0004199683,0.0003361095,0.0003820813,0.0002231232,0.0003049762,0.0003492796,0.0003103414,0.000610473],"category_scores_gemma":[0.0004032606,0.0001800381,0.0001492441,0.0003301792,0.0002241987,0.000177265,0.0003249395,0.0003218149,0.0002200358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003370132,"about_ca_system_score_gemma":0.0001828995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006366601,"about_ca_topic_score_gemma":0.0007287963,"domain_scores_codex":[0.9997074,0.00003520424,0.00001293064,0.00007880501,0.0001168651,0.00004865479],"domain_scores_gemma":[0.9996954,0.00006261053,0.00009366786,0.00001557358,0.00007774875,0.00005506465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006057084,0.00001360571,0.0003330656,0.00002543862,0.000006749086,0.00005902749,0.00002419777,0.00005117419,0.9982274,0.00002270778,0.00003212607,0.00114392],"study_design_scores_gemma":[0.00001792752,0.0003006728,0.01443326,0.00001051095,0.00001517836,0.0005393461,0.00006027413,0.003381578,0.9796848,0.00006870156,0.001474964,0.00001271799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928429,0.0008585752,0.005071332,0.00003489702,0.00001747158,0.0000343201,0.0001653262,0.0001244388,0.000850686],"genre_scores_gemma":[0.9871833,0.0005928134,0.009663003,0.00009748162,0.00001536474,0.00006048645,0.0003904895,0.00003562889,0.00196125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006366601,"threshold_uncertainty_score":0.002445281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006007437867181871,"score_gpt":0.2426060047275912,"score_spread":0.2365985668604094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}