{"id":"W2005693512","doi":"10.1110/ps.9.2.332","title":"Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry","year":2000,"lang":"en","type":"article","venue":"Protein Science","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":244,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; Natural Sciences and Engineering Research Council of Canada; University of California, San Francisco; National Institute on Aging; National Institutes of Health","keywords":"Chemistry; Peptide; Electrospray ionization; Crystallography; Circular dichroism; Histidine; Cooperativity; Mass spectrometry; Divalent; Binding site; Cooperative binding; Stoichiometry; Ion; Dissociation constant; Biophysics; Biochemistry; Amino acid; Physical chemistry; Chromatography; Biology; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000480362,0.0001465238,0.000117714,0.00006583063,0.0002795446,0.00007034748,0.0008186648,0.00006367226,0.00009466241],"category_scores_gemma":[0.0002247076,0.0001098833,0.00008697328,0.000681783,0.0002851216,0.00001699014,0.000188552,0.00008590947,0.00002578537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003481915,"about_ca_system_score_gemma":0.000158033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003297575,"about_ca_topic_score_gemma":0.00000134883,"domain_scores_codex":[0.9984036,0.00005591136,0.0002127103,0.0004846857,0.000465703,0.0003773856],"domain_scores_gemma":[0.9991153,0.000004080506,0.00008599972,0.0005543039,0.00008500669,0.0001553504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004922497,0.00002514722,0.001709489,0.00001553512,0.00000474022,4.210486e-7,0.00002579468,0.00001802342,0.9805976,0.00002129269,0.0001896773,0.01734302],"study_design_scores_gemma":[0.0001558097,0.0001689015,0.00142952,0.00008712599,0.000003886629,0.000002094187,0.00002901868,0.00002792457,0.9926386,0.00009879759,0.005198572,0.0001597608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965721,0.001051361,0.0003406995,0.0003425711,0.00004521927,0.001102659,0.00002666634,0.00001350477,0.0005052602],"genre_scores_gemma":[0.9928875,0.0000495777,0.00545904,0.00008269701,0.00006820622,0.0001167469,0.000003793928,0.00001367676,0.001318776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01718326,"threshold_uncertainty_score":0.4480912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006007437867181871,"score_gpt":0.2426060047275912,"score_spread":0.2365985668604094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}