{"id":"W2005712021","doi":"10.1093/nar/gkr959","title":"COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines","year":2011,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Gene; Cancer; Genetics; Computational biology; Cancer cell lines; Cell culture; Cancer cell; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00117901,0.001735087,0.002294433,0.004351434,0.00105195,0.001024984,0.002715158,0.000829575,0.03375999],"category_scores_gemma":[0.001548354,0.00114929,0.000819977,0.004494239,0.0002904728,0.0006244179,0.001176088,0.0009680825,0.02493687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001000216,"about_ca_system_score_gemma":0.001545627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004379184,"about_ca_topic_score_gemma":0.008677643,"domain_scores_codex":[0.9991379,0.0001300201,0.0001219897,0.0001356042,0.0003659109,0.000108632],"domain_scores_gemma":[0.9989626,0.0003396014,0.0001184564,0.0002946697,0.0001641212,0.000120458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00223212,0.0002596139,0.003360412,0.003236549,0.0001814791,0.0009886117,0.000266283,0.003670951,0.6196764,0.00342007,0.2814875,0.08122014],"study_design_scores_gemma":[0.0008936091,0.0004705507,0.01400847,0.0001956007,0.0003079381,0.002761549,0.0000633625,0.01349146,0.4499816,0.001473619,0.5161486,0.000203633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"dataset","genre_gemma":"empirical","genre_scores_codex":[0.0383925,0.003746581,0.1424966,0.000500588,0.0001818818,0.001623639,0.7130976,0.08103251,0.01892807],"genre_scores_gemma":[0.04282622,0.001869566,0.09021049,0.0002209096,0.00003381877,0.003187775,0.8447824,0.007340233,0.009528613],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03375999,"threshold_uncertainty_score":0.1129384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07328573762105596,"score_gpt":0.3728212283021065,"score_spread":0.2995354906810506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}