{"id":"W2005731274","doi":"10.4137/lpi.s13258","title":"Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding","year":2013,"lang":"en","type":"article","venue":"Lipid Insights","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genome Canada; Wellcome Trust; GlaxoSmithKline; Ontario Ministry of Research and Innovation; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; Chemistry; Receptor; BRD4; Apolipoprotein B; Pharmacology; Cell biology; Biochemistry; Biology; Cholesterol; Histone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006112882,0.0001759052,0.000181361,0.0001091207,0.00009382594,0.000130918,0.0001501884,0.0001281566,0.0008497782],"category_scores_gemma":[0.00006946551,0.00007668301,0.0001227981,0.00008405613,0.0001130223,0.0001117159,0.0001116241,0.0002152948,0.000257536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002155014,"about_ca_system_score_gemma":0.0001500122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005573616,"about_ca_topic_score_gemma":0.001183673,"domain_scores_codex":[0.9999603,0.000006775157,0.000005949863,0.000007674887,0.000008689772,0.00001061506],"domain_scores_gemma":[0.999966,0.000005377776,0.0000118623,0.000003765545,0.000003935823,0.000008957785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003924112,0.00002852649,0.0003545274,0.00006980309,0.000005055376,0.0001029862,0.00001947147,0.000109273,0.9962112,0.00009250132,0.00002866817,0.002585622],"study_design_scores_gemma":[0.0001192826,0.001205767,0.004481971,0.000004649291,0.00002308732,0.0005808811,0.00002707549,0.0008427286,0.9885001,0.0000315839,0.004174914,0.000008038068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948416,0.002511707,0.001360678,0.00005443442,0.00001023356,0.00002249321,0.0002049262,0.00002679948,0.0009671745],"genre_scores_gemma":[0.9936666,0.001982001,0.002155904,0.00003198096,0.000008114985,0.00003538863,0.0002973,0.000004585347,0.00181803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008497782,"threshold_uncertainty_score":0.002842784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00809923419687296,"score_gpt":0.209853375109647,"score_spread":0.201754140912774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}