{"id":"W2005731274","doi":"10.4137/lpi.s13258","title":"Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding","year":2013,"lang":"en","type":"article","venue":"Lipid Insights","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genome Canada; Wellcome Trust; GlaxoSmithKline; Ontario Ministry of Research and Innovation; Pfizer; Eli Lilly and Company","keywords":"Bromodomain; Chemistry; Receptor; BRD4; Apolipoprotein B; Pharmacology; Cell biology; Biochemistry; Biology; Cholesterol; Histone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001542835,0.0001801574,0.0002242465,0.0000776773,0.0001046662,0.00001957567,0.0001688887,0.0002045832,0.0000429828],"category_scores_gemma":[0.0003980017,0.0001298198,0.0000801352,0.0002282169,0.0002041661,0.00003080916,0.0001055734,0.0001110643,0.000009357004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002006595,"about_ca_system_score_gemma":0.00004467888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007312829,"about_ca_topic_score_gemma":0.00002945464,"domain_scores_codex":[0.9986825,0.0001273118,0.0004447502,0.0003434146,0.0002329472,0.0001690475],"domain_scores_gemma":[0.9990399,0.00002275589,0.000330982,0.0003780673,0.00016142,0.00006691241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003660039,0.0001199652,0.0006859333,0.00004552717,0.00002656821,9.190058e-9,0.0001299924,0.00001868938,0.9900647,0.0002248224,0.006183126,0.002464069],"study_design_scores_gemma":[0.0005776242,0.0002170601,0.001077958,0.00008479997,0.00001339085,0.000001407663,0.00006161308,0.0002116997,0.9790967,0.0001273455,0.01837336,0.0001570783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967563,0.0004723571,0.0005684026,0.0007965309,0.0004274668,0.0007944253,0.00002943025,0.00001373822,0.0001413811],"genre_scores_gemma":[0.9969813,0.0001689069,0.001397545,0.00005728362,0.0003849133,0.00006380845,0.000183573,0.00002153625,0.0007411996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01219023,"threshold_uncertainty_score":0.5293896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00809923419687296,"score_gpt":0.209853375109647,"score_spread":0.201754140912774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}