{"id":"W2005744558","doi":"10.1126/science.288.5466.640","title":"Architecture of RNA Polymerase II and Implications for the Transcription Mechanism","year":2000,"lang":"en","type":"article","venue":"Science","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":620,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biological and Environmental Research; Basic Energy Sciences; National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; Association of Medical Research Charities; American Cancer Society; Deutsche Forschungsgemeinschaft; U.S. Department of Energy","keywords":"Proofreading; Transcription (linguistics); RNA; Polymerase; RNA polymerase II; DNA; Protein subunit; RNA polymerase; Transcription factor II D; Biology; Biophysics; Chemistry; Molecular biology; Genetics; RNA-dependent RNA polymerase; Gene; Gene expression; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971975,0.00004105912,0.00003523751,0.00001349777,0.0002586806,0.000009759231,0.0001678193,0.00002553617,0.00002383079],"category_scores_gemma":[0.00002593638,0.00002747848,0.00002506673,0.00006381806,0.0001552745,0.000002660669,0.00001455389,0.00001522715,7.063988e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001428559,"about_ca_system_score_gemma":0.0000335735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004823278,"about_ca_topic_score_gemma":0.000002747005,"domain_scores_codex":[0.9996386,0.000008141533,0.00005918614,0.0001473564,0.00005099697,0.00009576078],"domain_scores_gemma":[0.9997353,0.000008732714,0.00001901271,0.0001758006,0.00003312888,0.0000280558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001402059,0.000005985895,0.000001846801,0.000002221918,0.000001845009,6.372746e-9,0.00004049682,0.000004127277,0.9114806,0.001973198,0.00001135137,0.08646432],"study_design_scores_gemma":[0.00007846949,0.000140442,0.0003356802,0.00000295799,0.000005682304,0.000003495063,0.00001006944,0.0000293356,0.9856073,0.006054656,0.007692928,0.00003898628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9532717,0.001081247,0.04275883,0.001807134,0.00006920774,0.0003406482,0.00003461691,0.000005198853,0.0006313822],"genre_scores_gemma":[0.9967447,0.0001656368,0.002274003,0.0001628941,0.00003805324,0.0000360296,0.000001897352,0.000003102937,0.0005737034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08642533,"threshold_uncertainty_score":0.1989588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103526879755884,"score_gpt":0.2474017493181038,"score_spread":0.2370490613425154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}