{"id":"W2005744558","doi":"10.1126/science.288.5466.640","title":"Architecture of RNA Polymerase II and Implications for the Transcription Mechanism","year":2000,"lang":"en","type":"article","venue":"Science","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":620,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Biological and Environmental Research; Basic Energy Sciences; National Center for Research Resources; National Institute of General Medical Sciences; National Institutes of Health; Association of Medical Research Charities; American Cancer Society; Deutsche Forschungsgemeinschaft; U.S. Department of Energy","keywords":"Proofreading; Transcription (linguistics); RNA; Polymerase; RNA polymerase II; DNA; Protein subunit; RNA polymerase; Transcription factor II D; Biology; Biophysics; Chemistry; Molecular biology; Genetics; RNA-dependent RNA polymerase; Gene; Gene expression; Philosophy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001554177,0.0003513843,0.0003359245,0.0002058232,0.0004359932,0.001241936,0.0007223344,0.0005773528,0.001628377],"category_scores_gemma":[0.0002969834,0.0003977785,0.0003079438,0.0002622128,0.0009786506,0.0009396547,0.0002914131,0.0006472222,0.001316709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001072713,"about_ca_system_score_gemma":0.0008831368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001490418,"about_ca_topic_score_gemma":0.001281035,"domain_scores_codex":[0.999922,0.00001773474,0.000004554102,0.00002061166,0.00002229519,0.00001276756],"domain_scores_gemma":[0.9999223,0.00001121258,0.00001461309,0.00001188134,0.00001360819,0.00002639235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002664567,0.00006709204,0.002635444,0.0004133396,0.00002978583,0.001006729,0.0005975847,0.2208587,0.2749071,0.4724966,0.001758781,0.02496234],"study_design_scores_gemma":[0.0001647497,0.0003066306,0.004405416,0.0002165772,0.00005132428,0.0008060344,0.0003978307,0.4999366,0.02560255,0.4015938,0.06641669,0.0001018442],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6445662,0.01842083,0.2319035,0.003531119,0.0004277659,0.0001225086,0.0003863242,0.001123734,0.09951808],"genre_scores_gemma":[0.946423,0.004408218,0.0406341,0.000185895,0.0001060942,0.000150696,0.0003292382,0.00008592241,0.007676926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001628377,"threshold_uncertainty_score":0.007783175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103526879755884,"score_gpt":0.2474017493181038,"score_spread":0.2370490613425154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}