{"id":"W2005756420","doi":"10.1021/bi0258142","title":"Positive Heat Capacity Change upon Specific Binding of Translation Initiation Factor eIF4E to mRNA 5‘ Cap","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Science Foundation","keywords":"Isothermal titration calorimetry; Enthalpy; Chemistry; Calorimetry; Thermodynamics; Heat capacity; EIF4E; Intramolecular force; Entropy (arrow of time); Protonation; Crystallography; Physical chemistry; Stereochemistry; Messenger RNA; Biochemistry; Organic chemistry; Translation (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008572405,0.0001719748,0.0001521292,0.00004499812,0.00006335301,0.00001644124,0.000137357,0.0002358254,0.0001837778],"category_scores_gemma":[0.00003490368,0.0001827903,0.00009616467,0.0001092424,0.00002593423,0.000007733621,0.00002700369,0.00006105451,0.00002612559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002929068,"about_ca_system_score_gemma":0.00001067603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000187631,"about_ca_topic_score_gemma":0.000003461543,"domain_scores_codex":[0.9990352,0.00003837203,0.0002164581,0.0003356942,0.0001662738,0.0002079371],"domain_scores_gemma":[0.9994633,0.00001391451,0.00007315097,0.0002753714,0.00007213749,0.0001020991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003976224,0.0000470584,0.0001180094,0.00003655187,0.00001886953,0.000001097285,0.0002447283,0.000001588841,0.9937401,0.000008356053,0.0001586359,0.005585272],"study_design_scores_gemma":[0.0002239099,0.0001209651,0.0003867779,0.00005241624,0.000009217992,0.000006722735,0.00004708933,0.00002417176,0.9974589,0.00001007947,0.001454429,0.0002053423],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959651,0.0009404323,0.00108622,0.0002010126,0.0001159553,0.0002803913,0.0002160477,0.00001458798,0.001180299],"genre_scores_gemma":[0.997878,0.0001762545,0.001158913,0.00008254839,0.0003646783,0.00003930313,0.0001356199,0.00002189147,0.0001427588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00537993,"threshold_uncertainty_score":0.7453972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06385695983810204,"score_gpt":0.247424652335181,"score_spread":0.1835676924970789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}