{"id":"W2005756420","doi":"10.1021/bi0258142","title":"Positive Heat Capacity Change upon Specific Binding of Translation Initiation Factor eIF4E to mRNA 5‘ Cap","year":2002,"lang":"en","type":"article","venue":"Biochemistry","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Science Foundation","keywords":"Isothermal titration calorimetry; Enthalpy; Chemistry; Calorimetry; Thermodynamics; Heat capacity; EIF4E; Intramolecular force; Entropy (arrow of time); Protonation; Crystallography; Physical chemistry; Stereochemistry; Messenger RNA; Biochemistry; Organic chemistry; Translation (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002042894,0.0003090137,0.0003017074,0.00008130637,0.0001267208,0.0002320618,0.0002995661,0.0002483532,0.001877419],"category_scores_gemma":[0.0007251284,0.0001482248,0.0001534672,0.0001375633,0.0004858609,0.0002712912,0.0002345454,0.0005304415,0.0002410234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000305179,"about_ca_system_score_gemma":0.0001255045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004166964,"about_ca_topic_score_gemma":0.0004221864,"domain_scores_codex":[0.9998032,0.00003248313,0.000005921792,0.00004425679,0.00007752893,0.00003657084],"domain_scores_gemma":[0.999774,0.0001020697,0.00005106063,0.00001069458,0.0000384811,0.00002368496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001525948,0.0000147975,0.0009327673,0.0000995302,0.00001701238,0.00006842783,0.00006356442,0.0004805252,0.9953088,0.0001270218,0.00008547803,0.00264949],"study_design_scores_gemma":[0.000005878972,0.0001642896,0.009549,0.000005586807,0.00000867229,0.0001183417,0.00003568299,0.002746203,0.9864125,0.00009077278,0.0008474747,0.0000154628],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929986,0.0008918578,0.004237482,0.00009788553,0.00004055844,0.00001744987,0.0002239753,0.00009650131,0.001395595],"genre_scores_gemma":[0.9979342,0.0002306838,0.000914448,0.00005065881,0.000005943371,0.00001845974,0.0001625233,0.00001133686,0.0006717752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001877419,"threshold_uncertainty_score":0.006280601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06385695983810204,"score_gpt":0.247424652335181,"score_spread":0.1835676924970789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}