{"id":"W2005766127","doi":"10.1038/nm1546","title":"β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment","year":2007,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":424,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Hospital and Health Sciences Centre; Child and Family Research Institute; University of British Columbia","funders":"National Heart, Lung, and Blood Institute","keywords":"Glucose homeostasis; Internal medicine; Endocrinology; ABCA1; Insulin; Insulin resistance; Type 2 diabetes; Biology; Homeostasis; Diabetes mellitus; Medicine; Transporter; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001362321,0.0003192074,0.0006219223,0.0005289252,0.0001064514,0.0000124401,0.00009602496,0.0003865874,0.0001197678],"category_scores_gemma":[0.0008722551,0.0002037973,0.00006414662,0.0006975276,0.0001612862,0.00007564603,0.00004325632,0.0005413228,0.00003829361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001412406,"about_ca_system_score_gemma":0.0001064589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009401992,"about_ca_topic_score_gemma":0.00003693103,"domain_scores_codex":[0.9980063,0.00007602105,0.0004536537,0.0004686233,0.0005878845,0.000407478],"domain_scores_gemma":[0.9982281,0.0003466657,0.0001013731,0.0004217766,0.0002236346,0.0006784993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02724248,0.0008674152,0.01434062,0.0002382187,0.0002003847,0.0006969277,0.01432454,0.000002956444,0.6169828,0.0002815944,0.01225178,0.3125703],"study_design_scores_gemma":[0.009343208,0.002780554,0.4362777,0.0002845929,0.0002895215,0.0002200841,0.0009928187,0.000006075961,0.04557911,0.00005786645,0.5039408,0.0002276285],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.921827,0.05664006,0.00009608432,0.01910444,0.0006990687,0.0005868294,0.00001263905,0.00009801294,0.0009359225],"genre_scores_gemma":[0.9829755,0.00380021,0.0007842023,0.009027635,0.001968679,0.00001671846,0.00004146427,0.0000307689,0.001354773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5714037,"threshold_uncertainty_score":0.8310611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055099622013931,"score_gpt":0.2988142785194531,"score_spread":0.2882632822993138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}