{"id":"W2005783231","doi":"10.1038/mt.2008.99","title":"Bone-protective Effects of Nonviral Gene Therapy With Folate–Chitosan DNA Nanoparticle Containing Interleukin-1 Receptor Antagonist Gene in Rats With Adjuvant-induced Arthritis","year":2008,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"","keywords":"Arthritis; Interleukin 1 receptor antagonist; Gene delivery; Receptor antagonist; Cytokine; Bone remodeling; Chemistry; In vivo; Alkaline phosphatase; Inflammation; Endocrinology; Immunology; Pharmacology; Receptor; Biology; Genetic enhancement; Antagonist; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002038661,0.0004113895,0.0008457981,0.000250789,0.0001802784,0.00003789577,0.0001759028,0.0001238991,0.00005246978],"category_scores_gemma":[0.0000305983,0.0003087022,0.0001373195,0.00046837,0.0003650146,0.0001767523,0.0000298912,0.0004004039,0.00001030774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006239454,"about_ca_system_score_gemma":0.0002832415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002357367,"about_ca_topic_score_gemma":0.0001100352,"domain_scores_codex":[0.9973506,0.0003283191,0.0004562486,0.0005530152,0.0006215292,0.0006902378],"domain_scores_gemma":[0.9988457,0.0000748908,0.0001744383,0.0005245504,0.0001366085,0.0002438164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01160731,0.0005457482,0.006858205,0.00002142318,0.0003661502,0.002621684,0.002903199,0.000003973269,0.9322605,0.00003010782,0.000003305004,0.04277838],"study_design_scores_gemma":[0.02204738,0.01697705,0.009640139,0.0005984937,0.00000283692,0.0006329488,0.0002132775,0.00002522715,0.9493287,0.00005767438,0.0001273214,0.0003489905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808479,0.01641139,0.0003804977,0.0002311408,0.00006089526,0.001902442,0.00000866436,0.00007808657,0.00007901168],"genre_scores_gemma":[0.981876,0.01622321,0.0011117,0.0003021369,0.00004194319,0.0002963873,0.00002393374,0.0001106651,0.00001405645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04242939,"threshold_uncertainty_score":0.9999365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120109365068878,"score_gpt":0.2370283143328054,"score_spread":0.2258272206821166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}