{"id":"W2005785099","doi":"10.1172/jci35754","title":"Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":284,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Georgia Institute of Technology; American Heart Association","keywords":"Von Willebrand disease; Von Willebrand factor; Platelet; Chemistry; Platelet Glycoprotein GPIb-IX Complex; Platelet membrane glycoprotein; Platelet adhesiveness; Mutant; Glycoprotein Ib; ADAMTS13; Thrombospondin; Glycoprotein; Biophysics; Metalloproteinase; Immunology; Biochemistry; Biology; Platelet aggregation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004032959,0.0002226719,0.0007524724,0.0001179312,0.0001848312,0.00002538995,0.0001041708,0.0001551086,0.00004180436],"category_scores_gemma":[0.0003662931,0.0001339449,0.0001402802,0.0002444275,0.0003994057,0.0003643399,0.00001617274,0.0005588257,0.00002079006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004350499,"about_ca_system_score_gemma":0.0008860065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004714936,"about_ca_topic_score_gemma":0.00005754163,"domain_scores_codex":[0.9977193,0.00006982314,0.001047663,0.0002433213,0.0006737277,0.0002461344],"domain_scores_gemma":[0.9976438,0.0001261291,0.0008410143,0.0002482561,0.0003925526,0.0007482464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02070706,0.001689597,0.9536825,0.000191764,0.001119862,0.01122322,0.0004010892,0.0001758206,0.002419505,0.0007641802,0.003584705,0.004040731],"study_design_scores_gemma":[0.03271381,0.01800414,0.9264889,0.001360778,0.001041066,0.003175468,0.0001126611,0.000259643,0.007538579,0.00380641,0.004946194,0.0005523869],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959106,0.000131832,0.00005499331,0.002683487,0.00008927013,0.0003694493,0.000007245339,0.0000235813,0.0007294712],"genre_scores_gemma":[0.9958116,0.0001655065,0.001538972,0.00145985,0.000308839,0.000006474724,0.00006344265,0.00003550597,0.0006098395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02719361,"threshold_uncertainty_score":0.5462116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06294040595608047,"score_gpt":0.3417059067807617,"score_spread":0.2787655008246812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}