{"id":"W2005785099","doi":"10.1172/jci35754","title":"Platelet glycoprotein Ibα forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF","year":2008,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":284,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Georgia Institute of Technology; American Heart Association","keywords":"Von Willebrand disease; Von Willebrand factor; Platelet; Chemistry; Platelet Glycoprotein GPIb-IX Complex; Platelet membrane glycoprotein; Platelet adhesiveness; Mutant; Glycoprotein Ib; ADAMTS13; Thrombospondin; Glycoprotein; Biophysics; Metalloproteinase; Immunology; Biochemistry; Biology; Platelet aggregation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472118,0.0002474017,0.0001575922,0.00008415727,0.0001225725,0.0002211061,0.000139076,0.000219118,0.0007831992],"category_scores_gemma":[0.0002296037,0.000163528,0.0001979812,0.0000783313,0.0001412937,0.0001499824,0.0001171721,0.0002427938,0.0002197329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002699116,"about_ca_system_score_gemma":0.0001033889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006413592,"about_ca_topic_score_gemma":0.0005151692,"domain_scores_codex":[0.9998649,0.00001652776,0.0000101966,0.00002947308,0.00005340449,0.00002534889],"domain_scores_gemma":[0.999908,0.00001330955,0.0000388837,0.0000117207,0.000007501154,0.00002066427],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001519947,0.00003487613,0.001605843,0.00002289851,0.00003603609,0.00009016112,0.00002755014,0.0002826881,0.9958603,0.0002426289,0.00009468956,0.00155036],"study_design_scores_gemma":[0.000074757,0.0005269545,0.01936234,0.000009842881,0.00004349104,0.001405964,0.00002663208,0.005271123,0.9692821,0.0001846038,0.00379871,0.00001357342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979839,0.0003863631,0.001093097,0.00002817335,0.000008385519,0.000008929617,0.00005447907,0.00001854013,0.0004181605],"genre_scores_gemma":[0.9980882,0.0001247429,0.0008088553,0.00003669562,0.000002973024,0.000008778355,0.0002329813,0.00001438963,0.0006823907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007831992,"threshold_uncertainty_score":0.002620101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06294040595608047,"score_gpt":0.3417059067807617,"score_spread":0.2787655008246812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}