{"id":"W2005785799","doi":"10.1002/cbic.201200729","title":"Resin Acid Conversion with CYP105A1: An Enzyme with Potential for the Production of Pharmaceutically Relevant Diterpenoids","year":2013,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Interreg; Deutsche Bundesstiftung Umwelt","keywords":"Bioconversion; Chemistry; Substrate (aquarium); Enzyme; Abietic acid; Organic chemistry; Terpenoid; Stereochemistry; Resin acid; Rosin; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001685917,0.0002058079,0.0001570173,0.00001670859,0.0001237666,0.00003017428,0.0002737519,0.0001557972,0.0000364281],"category_scores_gemma":[0.00007169371,0.0001221083,0.00006552485,0.00008220577,0.0002595211,0.00001403362,0.00005367674,0.00009246171,0.000004258746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001102728,"about_ca_system_score_gemma":0.00007452419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000104357,"about_ca_topic_score_gemma":0.000002871727,"domain_scores_codex":[0.998913,0.00002482165,0.0001784621,0.0004442708,0.0001772501,0.0002621613],"domain_scores_gemma":[0.9990563,0.00001803337,0.0001279247,0.0004590953,0.0002409735,0.00009769078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001220716,0.0001298343,0.0001179517,0.00009459734,0.0001080085,0.000001417143,0.00002458524,0.00001235662,0.9946527,0.000006414473,0.002756313,0.0008750324],"study_design_scores_gemma":[0.0005817409,0.0005500342,0.0002370713,0.00003993095,0.000110275,0.00007341659,0.000159249,0.000214908,0.9945216,0.000007006266,0.003283571,0.000221247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967017,0.0003133052,0.00120026,0.0009422577,0.00007672928,0.0005656721,0.00003603297,0.00001819646,0.0001458213],"genre_scores_gemma":[0.9968137,0.00008265467,0.001414651,0.0001386345,0.0003289393,0.00008370648,0.0002222568,0.0000248292,0.0008905872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008036233,"threshold_uncertainty_score":0.4979431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008720672151055944,"score_gpt":0.2233069666848203,"score_spread":0.2145862945337643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}