{"id":"W2005818996","doi":"10.1038/clpt.2008.50","title":"Mice as Clinically Relevant Models for the Study of Cytochrome P450-dependent Metabolism","year":2008,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Research Nova Scotia","keywords":"Drug metabolism; Cytochrome P450; Biology; Computational biology; Drug; Xenobiotic; Drug discovery; Function (biology); Gene; Metabolism; Drug development; Pharmacology; Bioinformatics; Genetics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001034994,0.000927838,0.00173559,0.001402703,0.0001690206,0.0008685088,0.001074078,0.001153117,0.002868222],"category_scores_gemma":[0.0005029982,0.0002456251,0.0003527546,0.001082515,0.0004985413,0.0009015052,0.0004870178,0.001967783,0.002666253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004139348,"about_ca_system_score_gemma":0.0004775283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003211746,"about_ca_topic_score_gemma":0.0005778625,"domain_scores_codex":[0.9996071,0.00009938722,0.00003996939,0.00006360363,0.0001662981,0.0000235792],"domain_scores_gemma":[0.9996822,0.0001438252,0.00005811812,0.00002057088,0.00006595457,0.00002939724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002062135,0.0002709956,0.0004114764,0.01114726,0.0001018645,0.0007463378,0.00008481836,0.0004519663,0.07478181,0.01398553,0.02932847,0.8684833],"study_design_scores_gemma":[0.00005597592,0.0003540821,0.001048152,0.001390282,0.0001472519,0.003060138,0.00004302851,0.0001360655,0.01218705,0.003417264,0.9781312,0.00002949324],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00108158,0.9905773,0.002612559,0.000403078,0.0003283886,0.00003999066,0.000123387,0.00006969607,0.004763902],"genre_scores_gemma":[0.003714225,0.9891283,0.003507336,0.0005030105,0.0001780239,0.00008214499,0.0002481295,0.00001482129,0.00262393],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002868222,"threshold_uncertainty_score":0.009595215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4641948439067347,"score_gpt":0.5847167342678442,"score_spread":0.1205218903611096,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}