{"id":"W2005819950","doi":"10.1016/j.clinthera.2005.03.006","title":"The CONCEPT trial: A 1-year, multicenter, randomized,double-blind, double-dummy comparison of a stable dosing regimen of salmeterol/fluticasone propionate with an adjustable maintenance dosing regimen of formoterol/budesonide in adults with persistent asthma","year":2005,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Vancouver General Hospital","funders":"","keywords":"Medicine; Formoterol; Salmeterol; Regimen; Dosing; Budesonide/formoterol; Fluticasone propionate; Budesonide; Randomized controlled trial; Double blind; Fluticasone; Pharmacology; Internal medicine; Corticosteroid; Asthma; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002568923,0.002810754,0.006172404,0.0006492467,0.0006965688,0.001480071,0.002012959,0.003208465,0.008033366],"category_scores_gemma":[0.00291282,0.001055984,0.002583357,0.000507563,0.002661259,0.002822237,0.000747988,0.005213345,0.001541296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008763611,"about_ca_system_score_gemma":0.001625479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001342456,"about_ca_topic_score_gemma":0.001685394,"domain_scores_codex":[0.9990659,0.0004274932,0.00005777022,0.0002223008,0.00008936474,0.0001372502],"domain_scores_gemma":[0.9985492,0.0004339743,0.0003828773,0.0001284017,0.00009991967,0.0004057939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9922963,0.002388327,0.0001178667,0.0003126428,0.0003405338,0.00001322085,0.00002624818,0.0001143737,0.0008582724,0.0001667521,0.0004557963,0.002909674],"study_design_scores_gemma":[0.9830827,0.01608443,0.0002835002,0.000009616542,0.0001395327,0.000006381565,0.000009566425,0.0001061282,0.00007208405,0.00005012209,0.000149603,0.000006364238],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732477,0.007125495,0.001830259,0.002267519,0.0030175,0.006846763,0.002540583,0.000312975,0.002811237],"genre_scores_gemma":[0.9602888,0.004761633,0.005218908,0.003528797,0.002508834,0.01355314,0.002548254,0.00009493336,0.007496623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008033366,"threshold_uncertainty_score":0.0268743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08122762669967477,"score_gpt":0.3774367020759708,"score_spread":0.296209075376296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}