{"id":"W2005829971","doi":"10.1038/ncomms2304","title":"Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors","year":2012,"lang":"en","type":"article","venue":"Nature Communications","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":286,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"Basic Energy Sciences; National Institute of General Medical Sciences; National Cancer Institute; Eli Lilly Canada; Office of Science; National Institutes of Health; Wellcome Trust; Genome Canada; William Lawrence and Blanche Hughes Foundation; GlaxoSmithKline; Ontario Ministry of Economic Development and Innovation; American Society of Hematology; Eli Lilly and Company; Ministero dello Sviluppo Economico; U.S. Department of Energy; Pfizer; Canadian Institutes of Health Research; National Science Foundation","keywords":"Methyltransferase; Fusion protein; Chemistry; Drug discovery; Biochemistry; In vitro; PRC2; Transferase; In vivo; Plasma protein binding; Cell biology; Epigenetics; Enzyme; Biology; Methylation; Genetics; EZH2; DNA; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002786966,0.0000869711,0.00008091686,0.00002370983,0.0001555016,0.0000069359,0.000432902,0.0002337245,0.000001140917],"category_scores_gemma":[0.0001276005,0.000068997,0.00008439102,0.0001928444,0.000098687,0.000005553439,0.0001464113,0.0003388512,0.000001898232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001533526,"about_ca_system_score_gemma":0.0000382511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003127939,"about_ca_topic_score_gemma":0.00009700465,"domain_scores_codex":[0.9993371,0.0001444877,0.0001679962,0.0001075801,0.0001060141,0.0001368255],"domain_scores_gemma":[0.998623,0.00005472731,0.00008005003,0.001058069,0.0001373353,0.00004685428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006967508,0.00009796171,0.01494315,0.000005481315,0.00003317996,6.213592e-9,0.0002648126,0.0000720723,0.9820775,0.0004568291,0.001180307,0.0008617023],"study_design_scores_gemma":[0.0001197755,0.00002049579,0.002717648,0.000008092841,0.00003619511,6.140761e-7,0.00002951784,0.0001254378,0.9493308,0.00009544256,0.04742317,0.00009281883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9186224,0.07299212,0.002700788,0.0009510488,0.0002287824,0.0003119034,0.00009971327,0.00001127251,0.00408199],"genre_scores_gemma":[0.9964546,0.001327208,0.00168721,0.0001023424,0.00006488406,0.00001154955,0.0002294745,0.00001395629,0.0001087927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0778322,"threshold_uncertainty_score":0.2813616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01161579447270468,"score_gpt":0.2791971139596938,"score_spread":0.2675813194869892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}