{"id":"W2005845878","doi":"10.1107/s0108767302085616","title":"Enzymes: evolution of function from a structural perspective","year":2002,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations of Crystallography","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Western University","funders":"","keywords":"Perspective (graphical); Enzyme; Function (biology); Computational biology; Biology; Computer science; Cell biology; Biochemistry; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00173606,0.0006340415,0.0006471059,0.0008773378,0.0004883289,0.001834409,0.0008826993,0.001773795,0.00101727],"category_scores_gemma":[0.0013475,0.0004131629,0.0003255053,0.001059793,0.002621323,0.002783257,0.0007952712,0.002093839,0.0008995665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002423455,"about_ca_system_score_gemma":0.000879633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081,"about_ca_topic_score_gemma":0.0007203388,"domain_scores_codex":[0.9995479,0.0001239902,0.00004444167,0.0001223779,0.00009325938,0.0000679103],"domain_scores_gemma":[0.9994767,0.0001516403,0.00006089376,0.00009890945,0.0001241577,0.000087681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006787175,0.000175137,0.009288046,0.001241727,0.0001370018,0.0008818753,0.001309893,0.008751873,0.1831511,0.4317746,0.003951484,0.3586585],"study_design_scores_gemma":[0.0001629719,0.001016596,0.02375806,0.0006502473,0.0001360094,0.004487671,0.00125524,0.009382717,0.06631544,0.1971583,0.6955094,0.0001673279],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4189444,0.3510677,0.1073659,0.03779782,0.001177167,0.0001228547,0.0009415246,0.0007124676,0.08187018],"genre_scores_gemma":[0.718444,0.194029,0.06756148,0.003312994,0.0008497656,0.0001305461,0.0009170924,0.0002133221,0.01454176],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002423455,"threshold_uncertainty_score":0.01758343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00930087794534009,"score_gpt":0.230961359257327,"score_spread":0.2216604813119869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}