{"id":"W2005851491","doi":"10.1016/j.tiv.2009.12.002","title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin and β-naphthoflavone induce cellular hypertrophy in H9c2 cells by an aryl hydrocarbon receptor-dependant mechanism","year":2009,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Aryl hydrocarbon receptor; CYP1B1; Chemistry; Internal medicine; Atrial natriuretic peptide; Endocrinology; In vivo; Receptor; Oxidative stress; Gene expression; Pharmacology; Cytochrome P450; Transcription factor; Biology; Gene; Biochemistry; Medicine; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004456729,0.0003706228,0.0005351933,0.0002248092,0.0000804615,0.00002166774,0.0003128549,0.000731621,0.00006595918],"category_scores_gemma":[0.00003960591,0.0003768836,0.00007099417,0.000191959,0.0001325035,0.00001811922,0.0001193351,0.0005191591,0.00001493301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000478663,"about_ca_system_score_gemma":0.00007054343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005598233,"about_ca_topic_score_gemma":0.0000553967,"domain_scores_codex":[0.9975082,0.0002620179,0.0004898132,0.0009025808,0.0001462967,0.0006910796],"domain_scores_gemma":[0.9991699,0.0000356359,0.000122244,0.0004038825,0.00003797354,0.0002303697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005505159,0.0006860063,0.0001378946,0.00000725893,0.00001959577,0.0001355741,0.00006635923,0.00001495402,0.9953187,0.0001147956,0.0009957087,0.00195266],"study_design_scores_gemma":[0.00205333,0.001618209,0.0005941608,0.000007263204,0.00002015994,0.00005764604,0.00006680744,0.0003451633,0.9915249,0.0006582814,0.002631564,0.0004225612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963099,0.001579876,0.00007652973,0.0009533038,0.000354574,0.0003823097,0.00003973587,0.00002882424,0.0002748973],"genre_scores_gemma":[0.9937465,0.0006343732,0.0007653675,0.004259036,0.0001858181,0.00003713367,0.0001856173,0.00004035541,0.0001457906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003793823,"threshold_uncertainty_score":0.9998683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009479431241364933,"score_gpt":0.241401228880211,"score_spread":0.2319217976388461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}