{"id":"W2005859125","doi":"10.1111/cge.12583","title":"Establishing cancer risks associated with <i><scp>PMS2</scp></i> germline mutations in Lynch syndrome","year":2015,"lang":"en","type":"letter","venue":"Clinical Genetics","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Lynch syndrome; PMS2; Germline; Germline mutation; Genetics; Mutation; Cancer; Biology; Medicine; Cancer research; Gene; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001374728,0.0007548773,0.001866835,0.0003370076,0.00007952024,0.0001142544,0.0006111934,0.002900589,0.0001398387],"category_scores_gemma":[0.007359981,0.0006650538,0.0003333159,0.001034715,0.0006167232,0.00006261536,0.0002436129,0.006047153,0.00007634795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008017132,"about_ca_system_score_gemma":0.002629621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002564714,"about_ca_topic_score_gemma":0.0008719859,"domain_scores_codex":[0.9937316,0.0005199474,0.001857381,0.001284154,0.001494302,0.001112611],"domain_scores_gemma":[0.9925302,0.00398335,0.0008753209,0.001105066,0.001018583,0.0004874649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003741082,0.0003083131,0.1746785,0.0001881382,0.0004773469,0.002152857,0.0001992184,0.001034046,0.00001617508,3.200171e-7,0.819051,0.001856731],"study_design_scores_gemma":[0.006670775,0.003114729,0.2484524,0.002228834,0.002122138,0.0002500654,0.0001087395,0.00150513,0.00008971467,0.0003367934,0.7343911,0.0007295235],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.9317871,0.004981964,0.00007246572,0.05453214,0.003507616,0.001777372,0.0006187877,0.0002023075,0.002520241],"genre_scores_gemma":[0.3741843,0.003550954,0.007511043,0.5825639,0.008678437,0.0008227044,0.004200672,0.0009408863,0.01754714],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5576028,"threshold_uncertainty_score":0.9995801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1512927014883454,"score_gpt":0.4031380842241447,"score_spread":0.2518453827357992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}