{"id":"W2005895876","doi":"10.1523/jneurosci.2491-09.2009","title":"Interaction of Postsynaptic Density Protein-95 with NMDA Receptors Influences Excitotoxicity in the Yeast Artificial Chromosome Mouse Model of Huntington's Disease","year":2009,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research; Killam Trusts; Michael Smith Health Research BC","keywords":"Excitotoxicity; Huntingtin; NMDA receptor; Biology; Glutamate receptor; Cell biology; Neurodegeneration; Postsynaptic density; Mutant; Receptor; Molecular biology; Genetics; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001755322,0.0007229869,0.0005738813,0.0006092553,0.0002510304,0.0005057337,0.0004275252,0.0007521983,0.001548623],"category_scores_gemma":[0.0001745037,0.0003618916,0.0004075308,0.0003578999,0.0004568537,0.0003198765,0.0003347678,0.001359942,0.0004827048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005615981,"about_ca_system_score_gemma":0.0001939114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009431352,"about_ca_topic_score_gemma":0.00121795,"domain_scores_codex":[0.9996468,0.00005252127,0.00005368029,0.00008248347,0.0001118256,0.00005278796],"domain_scores_gemma":[0.9997991,0.00002747384,0.00006668231,0.00002080522,0.00001408784,0.00007202614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003052213,0.0001028946,0.0001954357,0.00002171806,0.00001346202,0.0001513932,0.00002799716,0.00005271807,0.9985785,0.00008645899,0.00003175593,0.0004324013],"study_design_scores_gemma":[0.0001712308,0.001923347,0.01160317,0.00002487403,0.00009618953,0.001241448,0.0001151674,0.00326983,0.9791765,0.000168226,0.002189402,0.00002054353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972022,0.0007029611,0.0009391975,0.0001276689,0.00003487646,0.0000307492,0.0003179114,0.00008053514,0.0005639077],"genre_scores_gemma":[0.9949512,0.0007745576,0.001172698,0.00007060496,0.00001295094,0.00009507571,0.0004545972,0.00003543472,0.002432826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548623,"threshold_uncertainty_score":0.005180657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03748313534061936,"score_gpt":0.2769709823685857,"score_spread":0.2394878470279663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}