{"id":"W2005900492","doi":"10.1074/jbc.m112.398842","title":"The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Ectodomain; Dimer; Peptidomimetic; Aminopeptidase; Peptide; Chemistry; Signal transduction; Endocytosis; Biochemistry; Stereochemistry; Biophysics; Amino acid; Biology; Leucine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278186,0.0002489746,0.0002847923,0.00007250392,0.0002033605,0.0003867076,0.0003075867,0.0004194618,0.0005490442],"category_scores_gemma":[0.0001718228,0.0001996773,0.0001559137,0.000132926,0.0002402918,0.0002936359,0.0001464109,0.0006476553,0.0002140902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000266915,"about_ca_system_score_gemma":0.0002827354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005903623,"about_ca_topic_score_gemma":0.0007192115,"domain_scores_codex":[0.9999367,0.00001112872,0.000004136893,0.00002000407,0.0000205431,0.000007454074],"domain_scores_gemma":[0.9999576,0.000007691996,0.000008951408,0.000003627082,0.000006824838,0.0000154179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001397725,0.0002069144,0.00461227,0.0003772094,0.00006563141,0.001965209,0.000326606,0.004528656,0.9573371,0.003951841,0.004743783,0.02048713],"study_design_scores_gemma":[0.0009949002,0.001606392,0.04658508,0.0001202336,0.0002269935,0.009706897,0.0009637522,0.09033584,0.722563,0.00780478,0.1189277,0.0001644328],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736544,0.008653387,0.01097704,0.0008209804,0.0001330361,0.00005304966,0.0004152238,0.0001424516,0.005150436],"genre_scores_gemma":[0.9798251,0.002517792,0.01223732,0.0003073056,0.00003336819,0.00001998201,0.001373281,0.00002091819,0.003664875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005903623,"threshold_uncertainty_score":0.001936555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02932151682485054,"score_gpt":0.2950851860286904,"score_spread":0.2657636692038399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}