{"id":"W2005942970","doi":"10.1182/blood-2009-03-211029","title":"Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":150,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institutes of Health; National Metal and Materials Technology Center; National Institute of Allergy and Infectious Diseases; Hospital for Sick Children","keywords":"Biology; FOXP3; Immunology; Central tolerance; T cell; Lymphopoiesis; Severe combined immunodeficiency; Immune system; Cell biology; Haematopoiesis; Stem cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515033,0.0001332846,0.0002646817,0.00006780718,0.0001566991,0.000005272158,0.0001557049,0.0002032597,0.000009283379],"category_scores_gemma":[0.00001169384,0.0001026636,0.00005748954,0.0001162701,0.0001348327,0.00004735186,0.00003972984,0.0001400136,0.000006154268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001447311,"about_ca_system_score_gemma":0.00004831242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003431082,"about_ca_topic_score_gemma":0.00001603921,"domain_scores_codex":[0.9990947,0.0001036357,0.0003302172,0.0002127643,0.00001710832,0.0002415367],"domain_scores_gemma":[0.9993625,0.0001727487,0.0002008251,0.0002030743,0.00005096434,0.000009906216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001169877,0.0005641402,0.001938169,0.00003630793,0.00005540372,6.284154e-7,0.0002122295,0.00000387344,0.9957281,0.0008543285,0.00003220927,0.0004576096],"study_design_scores_gemma":[0.001595845,0.0007594487,0.4171501,0.000016763,0.00005289286,0.00001954281,0.00003449067,6.05395e-7,0.5795144,0.0007289719,0.00005091006,0.00007601408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975535,0.001497171,0.0001718456,0.00006104903,0.00007538394,0.0004968259,0.0000831299,0.00001647312,0.00004463911],"genre_scores_gemma":[0.9993795,0.00005972887,0.0001154512,0.00001751899,0.000005364556,0.00004981348,0.0002574259,0.000006583933,0.0001086047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4162137,"threshold_uncertainty_score":0.4186499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008460567368203187,"score_gpt":0.2178583000327652,"score_spread":0.209397732664562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}