{"id":"W2005981959","doi":"10.1038/cdd.2009.161","title":"Granzymes and perforin in solid organ transplant rejection","year":2009,"lang":"en","type":"review","venue":"Cell Death and Differentiation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Perforin; Granzyme; Effector; Solid organ; Cytotoxic T cell; Immunology; Granulysin; Organ transplantation; Immune system; Biology; Granzyme A; Transplantation; Medicine; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006139911,0.001197175,0.001574585,0.001383469,0.0002011265,0.0009291747,0.0009586046,0.00128148,0.001987105],"category_scores_gemma":[0.0007382847,0.0002594044,0.000310382,0.00147109,0.0006871641,0.001608555,0.0008127619,0.002052298,0.001538635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000635604,"about_ca_system_score_gemma":0.0009357784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005434932,"about_ca_topic_score_gemma":0.001014423,"domain_scores_codex":[0.9998329,0.00002273901,0.0000305264,0.00002860304,0.00006911011,0.00001611092],"domain_scores_gemma":[0.9997721,0.00008612969,0.00004336994,0.00000870861,0.00006099698,0.00002858505],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001770843,0.00007052437,0.0001389545,0.005474133,0.00004881676,0.0004146691,0.00002493901,0.0003904779,0.002941346,0.002003921,0.03357128,0.9547438],"study_design_scores_gemma":[0.000072287,0.0001325356,0.0007833151,0.001802676,0.0001707057,0.003884976,0.00005332819,0.0002151238,0.001505997,0.003238571,0.9881198,0.00002058739],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001833164,0.9973713,0.000361493,0.0003677133,0.0008941771,0.000004205288,0.000009198414,0.000008966227,0.0007997088],"genre_scores_gemma":[0.001357311,0.9947584,0.0004158613,0.000333445,0.001252211,0.000009068322,0.00002989524,0.00000281124,0.001840994],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001987105,"threshold_uncertainty_score":0.006647527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01878864899302021,"score_gpt":0.2551717018638485,"score_spread":0.2363830528708283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}