{"id":"W2006003949","doi":"10.1074/jbc.m109219200","title":"Apoptotic Release of Histones from Nucleosomes","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital","funders":"National Institutes of Health; National Cancer Institute; Kidney Foundation of Canada; American Lebanese Syrian Associated Charities","keywords":"Apoptotic DNA fragmentation; Jurkat cells; ICAD; DNA fragmentation; Chromatin; Cell biology; Biology; Histone; Molecular biology; Histone H2A; Apoptosis; Nucleosome; Programmed cell death; DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001286688,0.0001961149,0.000167635,0.0002085865,0.0001569357,0.0003114526,0.0001918611,0.0001989749,0.001325344],"category_scores_gemma":[0.0001897708,0.0001074227,0.0002085832,0.0001500532,0.0001829288,0.0001577601,0.0001932087,0.0003657441,0.0003126754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003995434,"about_ca_system_score_gemma":0.0001720944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005883115,"about_ca_topic_score_gemma":0.0007706929,"domain_scores_codex":[0.9998621,0.0000136197,0.00000983475,0.00002995323,0.00004958316,0.00003481362],"domain_scores_gemma":[0.9998475,0.00002283688,0.00003566307,0.00002669331,0.00003340864,0.00003395437],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007898269,0.000007447146,0.0005462504,0.00003077964,0.000005342745,0.00007674101,0.00001922276,0.00001659533,0.9972301,0.0001001302,0.00002891389,0.001859485],"study_design_scores_gemma":[0.000009156872,0.0001350084,0.01206094,0.00000770858,0.00001134018,0.0005200512,0.00003605633,0.0002643192,0.984147,0.00007940533,0.002725438,0.000003541913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848828,0.003380185,0.007916574,0.00008587464,0.00006283574,0.0000177713,0.0003127766,0.0001008332,0.003240466],"genre_scores_gemma":[0.9914219,0.001166403,0.002195196,0.00006336651,0.00001634836,0.00001071477,0.0006523828,0.00001148617,0.004462217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325344,"threshold_uncertainty_score":0.004433692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856747662782308,"score_gpt":0.218022015424143,"score_spread":0.1994545387963199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}