{"id":"W2006003949","doi":"10.1074/jbc.m109219200","title":"Apoptotic Release of Histones from Nucleosomes","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":141,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital","funders":"National Institutes of Health; National Cancer Institute; Kidney Foundation of Canada; American Lebanese Syrian Associated Charities","keywords":"Apoptotic DNA fragmentation; Jurkat cells; ICAD; DNA fragmentation; Chromatin; Cell biology; Biology; Histone; Molecular biology; Histone H2A; Apoptosis; Nucleosome; Programmed cell death; DNA; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008177569,0.00009837157,0.000195871,0.00001185185,0.00002354362,0.000005264547,0.0001539555,0.000213986,0.0006205428],"category_scores_gemma":[0.0001162412,0.00006816952,0.0001759703,0.00003521188,0.00008062888,0.000002123602,0.00004130424,0.00009498542,0.000003259182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001059184,"about_ca_system_score_gemma":0.00001056718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002537997,"about_ca_topic_score_gemma":1.402968e-7,"domain_scores_codex":[0.9993039,0.00002134354,0.0003359185,0.0001281568,0.0001070519,0.000103627],"domain_scores_gemma":[0.9993522,0.00001787077,0.0003106681,0.0001425114,0.00009660977,0.00008012677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006221562,0.0001091015,0.0005233969,0.0000119304,0.0000357823,0.000007685577,0.00001057178,0.00003244152,0.99496,0.000006790012,0.0008805043,0.003359615],"study_design_scores_gemma":[0.0004369064,0.000238743,0.001889127,0.00002376425,0.00002347666,0.00004010282,0.00004010079,0.00009753425,0.9857518,0.0002808472,0.01107064,0.0001069546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947377,0.00378193,0.0002686636,0.00009186551,0.00009122196,0.00002412124,0.000009676511,0.000003100538,0.0009917618],"genre_scores_gemma":[0.9969038,0.001052736,0.0009602305,0.00004369061,0.0003747891,5.161841e-7,0.00001845104,0.000006466491,0.0006392932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01019014,"threshold_uncertainty_score":0.6794509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856747662782308,"score_gpt":0.218022015424143,"score_spread":0.1994545387963199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}