{"id":"W2006052471","doi":"10.1007/s10545-009-1150-8","title":"Coenzyme Q<sub>10</sub> is decreased in fibroblasts of patients with methylmalonic aciduria but not in mevalonic aciduria","year":2009,"lang":"en","type":"article","venue":"Journal of Inherited Metabolic Disease","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Western Ontario; Western University","funders":"Deutsche Forschungsgemeinschaft; California Department of Fish and Game","keywords":"Methylmalonic aciduria; Internal medicine; Methylmalonic acidemia; Coenzyme Q – cytochrome c reductase; Endocrinology; Metabolism; Methylmalonic acid; Mevalonic acid; Chemistry; Mitochondrion; Biochemistry; Medicine; Enzyme; Biosynthesis; Vitamin B12","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252493,0.0004174791,0.0002440682,0.0007619344,0.0003478337,0.0004716455,0.0001535393,0.0004262197,0.001778448],"category_scores_gemma":[0.0005765873,0.0002920478,0.0001950453,0.0003231153,0.0003103983,0.000167229,0.0002152164,0.000226562,0.0003342034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001630214,"about_ca_system_score_gemma":0.00008504112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001673752,"about_ca_topic_score_gemma":0.001334504,"domain_scores_codex":[0.9998135,0.00003081891,0.00002439402,0.00006162832,0.00004113459,0.00002857305],"domain_scores_gemma":[0.9997203,0.00005827413,0.00009449231,0.00002123847,0.00003973291,0.00006602285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002859211,0.0001028812,0.3408628,0.0001307231,0.0001940036,0.009698959,0.0009464429,0.00008166886,0.6360294,0.0001115459,0.0001569814,0.008825442],"study_design_scores_gemma":[0.00009235064,0.001038001,0.9168373,0.00001926136,0.0001669545,0.03185452,0.000950362,0.0001839169,0.04716687,0.0001546217,0.001516132,0.00001968991],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989365,0.0005037721,0.000126219,0.00001855457,0.000005898528,0.000002840452,0.00009481281,0.000004875449,0.0003064933],"genre_scores_gemma":[0.999278,0.0002145875,0.0001280067,0.00001717995,0.000004212339,0.000003762695,0.0001008857,0.000002805129,0.0002506811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001778448,"threshold_uncertainty_score":0.005949497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004886742987843992,"score_gpt":0.2251316357972852,"score_spread":0.2202448928094412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}