{"id":"W2006110359","doi":"10.1016/j.antiviral.2007.08.009","title":"Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes","year":2007,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Cidofovir; Thymidine kinase; Foscarnet; Virology; Herpes simplex virus; Ribonucleotide reductase; Recombinant DNA; DNA polymerase; Biology; Molecular biology; Nucleoside; Thymidine; Gene; Virus; DNA; Herpesviridae; Protein subunit; Biochemistry; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002290832,0.0002801682,0.0003247066,0.000440534,0.0001409762,0.0003670016,0.0002755023,0.0002289932,0.001842256],"category_scores_gemma":[0.0003354959,0.0001555095,0.0002876247,0.000193089,0.0001742123,0.000263443,0.0001259859,0.0004488696,0.0002195842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002087551,"about_ca_system_score_gemma":0.0002060414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001592297,"about_ca_topic_score_gemma":0.00279083,"domain_scores_codex":[0.9998391,0.00003946661,0.0000151556,0.00001538643,0.00003919393,0.00005167671],"domain_scores_gemma":[0.9997446,0.0001041249,0.00004312512,0.00002840405,0.00002533353,0.00005430174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00262309,0.0004081587,0.001001308,0.0001130005,0.00004119081,0.00009242284,0.00006149546,0.0005101704,0.9756084,0.0001953599,0.0002407378,0.01910473],"study_design_scores_gemma":[0.0002573929,0.006524513,0.01539946,0.00001776021,0.00008724665,0.0003325306,0.00004887479,0.001060359,0.9726175,0.00006758043,0.003571864,0.00001492878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918147,0.005189677,0.0003929202,0.00005151318,0.0000532659,0.0000223182,0.0001226123,0.00003820891,0.002314757],"genre_scores_gemma":[0.9963877,0.001551375,0.0004327507,0.00002486232,0.00003586505,0.000006483181,0.0002141218,0.000006650497,0.001340162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842256,"threshold_uncertainty_score":0.006163001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08441485098573778,"score_gpt":0.4094349847870372,"score_spread":0.3250201338012993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}