{"id":"W2006163739","doi":"10.2174/187152711799219398","title":"Interception of Cocaine by Enzyme or Antibody Delivered with Viral Gene Transfer: A Novel Strategy for Preventing Relapse in Recovering Drug Users","year":2011,"lang":"en","type":"review","venue":"CNS & Neurological Disorders - Drug Targets","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Ottawa; National Institute on Drug Abuse; Baylor University; University of Minnesota","keywords":"Butyrylcholinesterase; Viral vector; Monoclonal antibody; Drug; Pharmacology; Antibody; Virology; Vector (molecular biology); Addiction; Enzyme; Immunology; Biology; Chemistry; Medicine; Gene; Recombinant DNA; Biochemistry; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002317774,0.0005291805,0.0007010812,0.001078829,0.0001604465,0.0004690997,0.000543109,0.0009047679,0.00156947],"category_scores_gemma":[0.0001494417,0.0001496411,0.0002613585,0.0006569483,0.0003537303,0.0005866541,0.0002495333,0.0008381879,0.001320375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004712701,"about_ca_system_score_gemma":0.0004665009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007930634,"about_ca_topic_score_gemma":0.001664278,"domain_scores_codex":[0.9999461,0.000007259012,0.000005122093,0.0000124071,0.00002215941,0.000006950485],"domain_scores_gemma":[0.9999566,0.0000173708,0.000009144121,0.000001849246,0.000009162994,0.000005790878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007229918,0.0001644634,0.0002014524,0.004648576,0.00005691472,0.000297275,0.00004669668,0.0003561401,0.02480791,0.003971443,0.006753188,0.9586238],"study_design_scores_gemma":[0.00007487147,0.0006221776,0.002037932,0.001275994,0.0001339193,0.004424585,0.00008734166,0.0003629306,0.02019441,0.001979372,0.968763,0.00004349641],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001680697,0.9941192,0.001259466,0.0003243262,0.0001615263,0.00002003511,0.00002287248,0.00002484835,0.002387124],"genre_scores_gemma":[0.006470476,0.9897795,0.001167161,0.0001662974,0.00008399835,0.00002335112,0.00003400025,0.000003679578,0.002271438],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00156947,"threshold_uncertainty_score":0.005250454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03723339154334581,"score_gpt":0.3220450097602011,"score_spread":0.2848116182168552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}