{"id":"W2006163739","doi":"10.2174/187152711799219398","title":"Interception of Cocaine by Enzyme or Antibody Delivered with Viral Gene Transfer: A Novel Strategy for Preventing Relapse in Recovering Drug Users","year":2011,"lang":"en","type":"review","venue":"CNS & Neurological Disorders - Drug Targets","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Ottawa; National Institute on Drug Abuse; Baylor University; University of Minnesota","keywords":"Butyrylcholinesterase; Viral vector; Monoclonal antibody; Drug; Pharmacology; Antibody; Virology; Vector (molecular biology); Addiction; Enzyme; Immunology; Biology; Chemistry; Medicine; Gene; Recombinant DNA; Biochemistry; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005424833,0.0006675693,0.001249719,0.0001714972,0.00008977193,0.00002753206,0.0007042518,0.0004653294,0.00007039622],"category_scores_gemma":[0.0001137413,0.0004975222,0.0005000086,0.0002684807,0.0002452632,0.00001816654,0.000157343,0.0005736568,0.000003223422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003272778,"about_ca_system_score_gemma":0.0002219383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006303941,"about_ca_topic_score_gemma":0.001001048,"domain_scores_codex":[0.9965776,0.0004474979,0.0008685321,0.001145133,0.0002152902,0.0007459352],"domain_scores_gemma":[0.9988853,0.0001049607,0.0002692159,0.0005132282,0.00008630677,0.0001409551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03687046,0.003967245,0.000317146,0.009182948,0.001225997,0.00005173574,0.0005357331,0.0008189844,0.2088985,0.0000257346,0.001280288,0.7368253],"study_design_scores_gemma":[0.02681416,0.08780336,0.0003341607,0.006367863,0.002048424,0.0001642928,0.0004033915,0.002041833,0.04591979,0.0003518752,0.8204195,0.007331308],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2911961,0.700453,0.004544171,0.00004096267,0.0001034697,0.003033336,0.0005450445,0.00003743447,0.00004644904],"genre_scores_gemma":[0.08749861,0.9093752,0.0003268574,0.00009301982,0.00005973881,0.0003776464,0.001897706,0.0001359414,0.0002353126],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8191392,"threshold_uncertainty_score":0.9997476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03723339154334581,"score_gpt":0.3220450097602011,"score_spread":0.2848116182168552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}