{"id":"W2006189281","doi":"10.1016/j.yjmcc.2012.01.018","title":"The natriuretic peptides BNP and CNP increase heart rate and electrical conduction by stimulating ionic currents in the sinoatrial node and atrial myocardium following activation of guanylyl cyclase-linked natriuretic peptide receptors","year":2012,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research","keywords":"Internal medicine; Endocrinology; Atrial natriuretic peptide; Natriuretic peptide; Receptor; NPR1; Sinoatrial node; Heart failure; Medicine; Cardiology; Heart rate; Chemistry; Blood pressure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003184252,0.0002799034,0.000251919,0.0001437011,0.0001666453,0.0002889244,0.000246444,0.0002932666,0.001088138],"category_scores_gemma":[0.0004919699,0.0002939521,0.0002866266,0.00008634883,0.0005173195,0.0005942041,0.0003789094,0.0008581431,0.0001927076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002541734,"about_ca_system_score_gemma":0.0002133291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003619967,"about_ca_topic_score_gemma":0.0005443321,"domain_scores_codex":[0.999856,0.00005000363,0.00001009124,0.00002097915,0.00002722683,0.00003574925],"domain_scores_gemma":[0.9998137,0.00005795589,0.00003125812,0.00001524691,0.00001174984,0.00007006447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001137607,0.0000476675,0.0003857411,0.00004693278,0.0000155355,0.0001557036,0.00006263528,0.00006613548,0.9949136,0.0007910811,0.00007065044,0.002306679],"study_design_scores_gemma":[0.00162769,0.003312167,0.09924122,0.00003676476,0.0001832172,0.002301364,0.0003720913,0.006915959,0.8784254,0.003485325,0.004056573,0.00004208296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930821,0.002378818,0.00209304,0.0003403682,0.00007453532,0.00002069448,0.00006125007,0.00002502938,0.001924181],"genre_scores_gemma":[0.9944765,0.001886945,0.001995968,0.0001623118,0.00007313428,0.00004678652,0.00008947244,0.00001895697,0.00125001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001088138,"threshold_uncertainty_score":0.003640175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00873898057719586,"score_gpt":0.2398004481240509,"score_spread":0.2310614675468551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}