{"id":"W2006189794","doi":"10.1016/j.tox.2004.05.020","title":"H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation","year":2004,"lang":"en","type":"article","venue":"Toxicology","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":203,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Reactive oxygen species; Chemistry; Mitochondrion; Cytotoxicity; Biochemistry; Depolarization; Programmed cell death; Metabolite; Mitochondrial ROS; Biophysics; Biology; Apoptosis; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177177,0.0001637454,0.0001765163,0.00007298924,0.0001405523,0.00002083144,0.0001425772,0.00039952,0.00001889942],"category_scores_gemma":[0.0001913015,0.0001633537,0.00004939677,0.00006214697,0.0001784549,0.00001455436,0.0001574534,0.0001279179,0.00001328697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000752848,"about_ca_system_score_gemma":0.00006836125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002414656,"about_ca_topic_score_gemma":0.0002489027,"domain_scores_codex":[0.9989854,0.0001090723,0.0002224263,0.0003456025,0.00007821011,0.0002592963],"domain_scores_gemma":[0.99948,0.00002954468,0.0001248541,0.0002356039,0.00006433092,0.00006566241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001426666,0.00005318112,0.0002875857,0.000006372375,0.00003371928,0.000003203193,0.0002088016,0.00001362679,0.9919562,0.006926987,0.0001502163,0.0002174268],"study_design_scores_gemma":[0.00112726,0.0007624698,0.006082159,0.000004482841,0.00001567862,0.0001345174,0.0002119312,0.00001503831,0.9704641,0.01507268,0.005908635,0.0002010908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769866,0.0001603134,0.02036705,0.0004527917,0.0004704439,0.0003035672,0.00001482553,0.00003137561,0.001212977],"genre_scores_gemma":[0.9924608,0.0001070698,0.005993924,0.0005892887,0.0004931512,0.0000441255,0.0001814523,0.00001595154,0.0001142409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02149216,"threshold_uncertainty_score":0.6661369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01752655728760464,"score_gpt":0.2433958762321452,"score_spread":0.2258693189445406,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}