{"id":"W2006198762","doi":"10.1128/mcb.25.13.5404-5416.2005","title":"Transcription Factor NF-κB Differentially Regulates Death Receptor 5 Expression Involving Histone Deacetylase 1","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; Manitoba Health Research Council; Leukemia and Lymphoma Society","keywords":"Biology; HDAC3; Transcription factor; Histone deacetylase 2; Histone deacetylase; Histone deacetylase 5; Histone deacetylase inhibitor; HDAC1; Cancer research; NF-κB; Gene expression; Regulation of gene expression; Molecular biology; Cell biology; HDAC4; HDAC11; Signal transduction; Histone; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001127683,0.0002684969,0.0001459988,0.0001526782,0.0001324354,0.0002657259,0.000162843,0.0001263558,0.00195768],"category_scores_gemma":[0.00008414636,0.0001015974,0.000305362,0.0001138039,0.0001603676,0.0002106269,0.0001538325,0.000345814,0.0004852976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003866516,"about_ca_system_score_gemma":0.0001746919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005544715,"about_ca_topic_score_gemma":0.0008777425,"domain_scores_codex":[0.9998325,0.00001659568,0.0000128239,0.00005158115,0.00004181434,0.00004454604],"domain_scores_gemma":[0.9999418,0.000004662925,0.00002184037,0.000005805911,0.00001109876,0.00001479642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002011046,0.00002757192,0.0007528164,0.0000831972,0.00001061569,0.00007312353,0.00002863946,0.00004583771,0.9945379,0.0002104565,0.0001000176,0.003928707],"study_design_scores_gemma":[0.00005427785,0.000332475,0.02055832,0.00003206635,0.00005467534,0.0004800863,0.0001226869,0.001078401,0.9660668,0.0001671321,0.01104273,0.00001046551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686775,0.01594186,0.00763886,0.000198145,0.0001819158,0.00004528389,0.0006393096,0.0001532431,0.006523932],"genre_scores_gemma":[0.9889122,0.003003071,0.002490591,0.0000956638,0.00002093977,0.0000239493,0.0006313041,0.00001232983,0.004809941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00195768,"threshold_uncertainty_score":0.00654912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009236138802526368,"score_gpt":0.230365372084935,"score_spread":0.2211292332824087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}