{"id":"W2006198762","doi":"10.1128/mcb.25.13.5404-5416.2005","title":"Transcription Factor NF-κB Differentially Regulates Death Receptor 5 Expression Involving Histone Deacetylase 1","year":2005,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; Manitoba Health Research Council; Leukemia and Lymphoma Society","keywords":"Biology; HDAC3; Transcription factor; Histone deacetylase 2; Histone deacetylase; Histone deacetylase 5; Histone deacetylase inhibitor; HDAC1; Cancer research; NF-κB; Gene expression; Regulation of gene expression; Molecular biology; Cell biology; HDAC4; HDAC11; Signal transduction; Histone; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001221228,0.0002897243,0.0002404166,0.00008167746,0.0001650948,0.00003236001,0.0001448246,0.0004325991,0.0001282655],"category_scores_gemma":[0.00002012164,0.0002570591,0.0001533618,0.00005546266,0.00008984993,0.000009560921,0.00009515705,0.0001226471,0.00001201856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002737701,"about_ca_system_score_gemma":0.00002935974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001882699,"about_ca_topic_score_gemma":0.00001673169,"domain_scores_codex":[0.9984869,0.0001511129,0.0002981867,0.0006027649,0.0001091129,0.0003518609],"domain_scores_gemma":[0.9993384,0.000006817185,0.0001042261,0.0003396177,0.0000630265,0.0001478991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008332975,0.00007206087,0.0001372614,0.00002035408,0.00003674229,0.000003024457,0.00007066136,0.00002749236,0.9875208,0.001051271,0.00009097601,0.01088598],"study_design_scores_gemma":[0.0007369026,0.0002711141,0.0002676497,0.00001991793,0.00003251302,0.00001246852,0.00002193218,0.0002525926,0.9774542,0.0003030293,0.02030273,0.000324909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.93663,0.009392191,0.0531473,0.0001611736,0.0002332049,0.0002404381,0.00002129421,0.00003498696,0.0001394281],"genre_scores_gemma":[0.9940283,0.0007341122,0.003068875,0.000181285,0.0002643731,0.00002279572,0.0008235502,0.00004215015,0.0008346174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05739826,"threshold_uncertainty_score":0.9999881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009236138802526368,"score_gpt":0.230365372084935,"score_spread":0.2211292332824087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}