{"id":"W2006216209","doi":"10.1021/jm7010673","title":"Structure–Activity Relationships of C6-Uridine Derivatives Targeting <i>Plasmodia</i> Orotidine Monophosphate Decarboxylase","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Center for Research Resources","keywords":"Uridine; Chemistry; Plasmodium falciparum; Biochemistry; Enzyme; Nucleotide salvage; Stereochemistry; Nucleotide; RNA; Malaria; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001664365,0.0003132543,0.0003328603,0.0001643169,0.00009013167,0.0001718892,0.0002896216,0.0002680511,0.001454733],"category_scores_gemma":[0.0001815602,0.0001188878,0.0002304237,0.0001872196,0.0001020643,0.0001466965,0.0001113444,0.0003909162,0.0002871556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000177854,"about_ca_system_score_gemma":0.0001293943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007284762,"about_ca_topic_score_gemma":0.001113875,"domain_scores_codex":[0.9998977,0.00002497511,0.000009693007,0.00001999416,0.00002574447,0.00002195951],"domain_scores_gemma":[0.999903,0.00001849849,0.00002850011,0.000007101602,0.00002002107,0.00002294311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006629545,0.0002286104,0.0002436579,0.0002053737,0.00002377402,0.00008640542,0.00001859202,0.001209166,0.9896064,0.0001669885,0.0001526052,0.007395238],"study_design_scores_gemma":[0.00009097173,0.006040907,0.002819292,0.00001661433,0.00006497074,0.0002108339,0.0000135465,0.001971984,0.9836447,0.00004094532,0.005068799,0.00001636525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779389,0.01435588,0.001486427,0.0001286612,0.00005520818,0.000089582,0.0006276048,0.00006948851,0.005248148],"genre_scores_gemma":[0.9906853,0.004912788,0.002110407,0.00006363985,0.00001276836,0.00002528825,0.0006486584,0.000009129939,0.001532063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001454733,"threshold_uncertainty_score":0.0048666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02365364411498889,"score_gpt":0.2625274203392105,"score_spread":0.2388737762242216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}