{"id":"W2006216209","doi":"10.1021/jm7010673","title":"Structure–Activity Relationships of C6-Uridine Derivatives Targeting <i>Plasmodia</i> Orotidine Monophosphate Decarboxylase","year":2008,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Malaria Research and Control","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Center for Research Resources","keywords":"Uridine; Chemistry; Plasmodium falciparum; Biochemistry; Enzyme; Nucleotide salvage; Stereochemistry; Nucleotide; RNA; Malaria; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007714058,0.0002016541,0.0006861893,0.00009402039,0.0001183621,0.000005847306,0.000182356,0.0001511293,0.0003234758],"category_scores_gemma":[0.003079969,0.0001515507,0.0001904648,0.0002646444,0.00021291,0.0001549915,0.00003050694,0.00120283,0.000001160405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001059391,"about_ca_system_score_gemma":0.0006535831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001339103,"about_ca_topic_score_gemma":6.95711e-7,"domain_scores_codex":[0.99775,0.0000897941,0.00070164,0.0001691543,0.0009816024,0.0003078187],"domain_scores_gemma":[0.9975759,0.0003436156,0.0007287576,0.0002140498,0.0006462543,0.0004914025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003108075,0.0002326635,0.02010293,0.0002857854,0.0002122215,0.0008058586,0.0002100241,0.00006354782,0.9719393,0.00001626229,0.001893844,0.001129467],"study_design_scores_gemma":[0.005022427,0.0006481498,0.05091925,0.000377472,0.0001670515,0.002156607,0.0002025764,0.000375885,0.9394411,0.0002174179,0.000340531,0.0001315283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926858,0.002254069,0.000482539,0.003279128,0.00007329788,0.0001434383,0.00001010725,0.00001138639,0.001060218],"genre_scores_gemma":[0.9970989,0.0004127318,0.00151519,0.00008031626,0.0006575271,0.00000176839,0.000007878333,0.00001687234,0.0002088126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03249822,"threshold_uncertainty_score":0.6180056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02365364411498889,"score_gpt":0.2625274203392105,"score_spread":0.2388737762242216,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}