{"id":"W2006219803","doi":"10.1074/jbc.m110983200","title":"Crystal Structure of a Bacterial Signal Peptidase Apoenzyme","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Oxyanion hole; Active site; Stereochemistry; Chemistry; Enzyme; Crystallography; Subtilisin; Hydrolase; Binding site; Crystal structure; Proteases; Molecular replacement; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348563,0.0002827947,0.0003133603,0.0001017977,0.0002442205,0.0005287187,0.0004768926,0.0003531944,0.001564419],"category_scores_gemma":[0.0002411086,0.0001351811,0.0001237138,0.0002195557,0.000167197,0.0002353157,0.0001908212,0.0007283593,0.0007860418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006456723,"about_ca_system_score_gemma":0.0005147716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002763901,"about_ca_topic_score_gemma":0.002015352,"domain_scores_codex":[0.9999217,0.000008267112,0.000003987696,0.00001815866,0.00003427986,0.00001358035],"domain_scores_gemma":[0.999927,0.00001144868,0.00001097727,0.000004393929,0.00002291846,0.00002322966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002120202,0.0003893508,0.00567974,0.0005003161,0.0001118531,0.001522639,0.0003401767,0.005638348,0.9355026,0.003199549,0.01021014,0.03478503],"study_design_scores_gemma":[0.001517352,0.001520062,0.03991524,0.0001125984,0.0002307831,0.004111067,0.0005015067,0.03398341,0.705757,0.003110627,0.2091049,0.0001354124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976703,0.008374259,0.004879415,0.00108479,0.0002684823,0.00006798395,0.001949624,0.0002592984,0.006413042],"genre_scores_gemma":[0.9561145,0.003781875,0.01181952,0.0003144326,0.00005239094,0.00006952226,0.01197422,0.00006721839,0.01580635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002763901,"threshold_uncertainty_score":0.005495667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0184095923677451,"score_gpt":0.2188027381680161,"score_spread":0.200393145800271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}