{"id":"W2006222270","doi":"10.1016/j.chembiol.2010.06.008","title":"Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity","year":2010,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"DNA gyrase; Chemical biology; Chemical genetics; Mechanism of action; Escherichia coli; Biological activity; Biology; Mode of action; Biochemistry; Chemical structure; Small molecule; Computational biology; Chemical synthesis; Chemistry; Structure–activity relationship; Drug discovery; Combinatorial chemistry; In vitro; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698481,0.0003812348,0.0002841214,0.0003007929,0.0001561943,0.0003234168,0.0002546259,0.0004792758,0.0011373],"category_scores_gemma":[0.0003031418,0.0001931089,0.0002062891,0.0003022683,0.0002048607,0.00030253,0.0002829778,0.0004832437,0.0004740176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053978,"about_ca_system_score_gemma":0.000173191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003505473,"about_ca_topic_score_gemma":0.0008438246,"domain_scores_codex":[0.9998524,0.00002717526,0.000005552184,0.00002711344,0.00004540569,0.00004225279],"domain_scores_gemma":[0.9998927,0.00002950782,0.00003198528,0.00001047718,0.00001673351,0.00001863939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006781187,0.00001221659,0.0001258485,0.00001163411,0.000002585599,0.00002202659,0.000004738351,0.0001073594,0.9986721,0.0001173242,0.00002180513,0.0008344495],"study_design_scores_gemma":[0.00000354602,0.00009654782,0.0008064131,0.000001304161,0.000007365618,0.00005387612,0.000008939263,0.0006430788,0.9975425,0.00004989859,0.0007844385,0.000002151525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765818,0.001378284,0.01812978,0.0002287621,0.00002345184,0.00003749828,0.0004966232,0.0001894681,0.00293445],"genre_scores_gemma":[0.9904959,0.0008383623,0.005984695,0.0001409292,0.00000990005,0.00002525428,0.0005868865,0.00002669038,0.001891366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0011373,"threshold_uncertainty_score":0.003804624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0242143119081207,"score_gpt":0.2873118106193606,"score_spread":0.2630974987112399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}