{"id":"W2006228171","doi":"10.1210/me.2007-0041","title":"Differential Regulation of the Human Adrenocorticotropin Receptor [Melanocortin-2 Receptor (MC2R)] by Human MC2R Accessory Protein Isoforms α and β in Isogenic Human Embryonic Kidney 293 Cells","year":2007,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Melanocortin; Biology; Receptor; Gene isoform; Melanocortin receptor; HEK 293 cells; Cell biology; Transfection; ACTH receptor; Molecular biology; Adrenocorticotropic hormone; Cell culture; Endocrinology; Gene; Biochemistry; Hormone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002591404,0.0002568017,0.0003356356,0.00017601,0.0001810038,0.0005688697,0.0002409439,0.0002364341,0.0007766277],"category_scores_gemma":[0.0001811175,0.0002000924,0.0004017513,0.0002439589,0.0001840652,0.0002049936,0.0002407133,0.0005228828,0.0006632345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002288629,"about_ca_system_score_gemma":0.0001509443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009095433,"about_ca_topic_score_gemma":0.0009220357,"domain_scores_codex":[0.9994411,0.00008642868,0.00008116877,0.0001171638,0.0001957956,0.00007845382],"domain_scores_gemma":[0.999903,0.00001675742,0.00001677142,0.0000189338,0.00002455125,0.00002000397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006991682,0.00001216603,0.0001085783,0.00001547231,0.000003522902,0.00004067014,0.00002210021,0.00001857527,0.9992027,0.0000450448,0.0000279966,0.0004332933],"study_design_scores_gemma":[0.00002377065,0.0001774646,0.007095542,0.000004982327,0.00002808902,0.0006149209,0.00007936103,0.001165811,0.9853178,0.00003910213,0.005440055,0.00001309927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852335,0.003720622,0.00700901,0.0001425487,0.0001049189,0.00007270733,0.001192216,0.0001246281,0.002399871],"genre_scores_gemma":[0.9858008,0.002211802,0.005879359,0.00009800628,0.00002752952,0.0001027515,0.002025183,0.00005192397,0.003802755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009095433,"threshold_uncertainty_score":0.002598047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007029098738904112,"score_gpt":0.2422508156325921,"score_spread":0.235221716893688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}