{"id":"W2006228171","doi":"10.1210/me.2007-0041","title":"Differential Regulation of the Human Adrenocorticotropin Receptor [Melanocortin-2 Receptor (MC2R)] by Human MC2R Accessory Protein Isoforms α and β in Isogenic Human Embryonic Kidney 293 Cells","year":2007,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Melanocortin; Biology; Receptor; Gene isoform; Melanocortin receptor; HEK 293 cells; Cell biology; Transfection; ACTH receptor; Molecular biology; Adrenocorticotropic hormone; Cell culture; Endocrinology; Gene; Biochemistry; Hormone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001913788,0.0003952853,0.0004445765,0.00017618,0.0002742154,0.00003596192,0.000540378,0.0003784954,0.0004774905],"category_scores_gemma":[0.00005795587,0.00034257,0.0002189842,0.0002017456,0.0002782696,0.00001445272,0.0004082919,0.0003647576,0.000006474357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006367028,"about_ca_system_score_gemma":0.00006421534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001331052,"about_ca_topic_score_gemma":0.0001188234,"domain_scores_codex":[0.9971185,0.000231939,0.0008236566,0.0007505412,0.0002773306,0.0007980768],"domain_scores_gemma":[0.9985805,0.000009692856,0.0004723693,0.0006749976,0.00009586911,0.0001665296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007740317,0.0001476351,0.001671956,0.00005845529,0.00007864831,0.000004266583,0.00005030225,0.000008892832,0.9951222,0.001265927,0.0007205229,0.0007938222],"study_design_scores_gemma":[0.001517912,0.0004598297,0.002884379,0.00005696572,0.00003599122,0.00001094369,0.00004922716,0.000006912675,0.9899045,0.0004814884,0.004220242,0.0003715909],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960655,0.0004265404,0.001950545,0.0001210319,0.0002527561,0.0009148715,0.00004733649,0.00002563645,0.0001957564],"genre_scores_gemma":[0.9976199,0.00004299169,0.0002983262,0.000144885,0.0001329566,0.00007843241,0.0004747481,0.00007019879,0.001137565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00521765,"threshold_uncertainty_score":0.9999026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007029098738904112,"score_gpt":0.2422508156325921,"score_spread":0.235221716893688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}