{"id":"W2006233042","doi":"10.1038/sj.leu.2403717","title":"Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis","year":2005,"lang":"en","type":"article","venue":"Leukemia","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Canadian Institutes of Health Research","keywords":"Cell biology; Lysosome; Cathepsin B; Cathepsin; Programmed cell death; Apoptosis; Biology; Mitochondrial permeability transition pore; Mitochondrion; Caspase; Cathepsin D; Caspase 2; Caspase 8; Mitochondrial apoptosis-induced channel; Cytochrome c; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000908614,0.0001230434,0.0001298265,0.00007147123,0.00004977376,0.00001595706,0.00004841217,0.0002006345,0.00001297655],"category_scores_gemma":[0.00002357969,0.0001188277,0.00003015551,0.00005998938,0.000024112,0.00001219507,0.00005767754,0.00007318204,0.000001137202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005933863,"about_ca_system_score_gemma":0.00005401962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001875942,"about_ca_topic_score_gemma":0.000226401,"domain_scores_codex":[0.9992462,0.00003611518,0.0001912126,0.000280492,0.0001098694,0.0001361398],"domain_scores_gemma":[0.9996579,0.00001019624,0.00008640616,0.0001652683,0.00003142847,0.00004880326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008978834,0.00002409094,0.0000799406,0.00001534563,0.00001269058,4.438152e-7,0.00008857199,0.0001064341,0.9928918,0.0008288349,0.00002321225,0.005838813],"study_design_scores_gemma":[0.001210187,0.0001774759,0.003540309,0.00001762398,0.00001621396,0.000006303806,0.0001049327,0.0006479405,0.9933688,0.0005821271,0.0001936516,0.0001344541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938173,0.00004063372,0.005535717,0.000102846,0.0001226284,0.000187833,0.000004138612,0.000007139541,0.0001817512],"genre_scores_gemma":[0.9977723,0.00004509734,0.001547026,0.00006037402,0.0001827388,0.00001331991,0.00005138804,0.00001552721,0.0003122129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005704359,"threshold_uncertainty_score":0.4845652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007911096800070235,"score_gpt":0.2174752646255249,"score_spread":0.2095641678254546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}