{"id":"W2006249760","doi":"10.1038/onc.2013.228","title":"Mitochondrial matrix proteases as novel therapeutic targets in malignancy","year":2013,"lang":"en","type":"review","venue":"Oncogene","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Leukemia and Lymphoma Society","keywords":"Proteases; Biology; Cell biology; Mitochondrial matrix; Mitochondrion; DNAJA3; Proteostasis; mitochondrial fusion; Biochemistry; Mitochondrial DNA; Enzyme; Gene; Cytosol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007323233,0.001077902,0.001564282,0.00164517,0.0002778717,0.001148389,0.001014568,0.001304771,0.002437072],"category_scores_gemma":[0.0008416332,0.0003226684,0.0003608593,0.001762177,0.000701533,0.001420552,0.0007187367,0.002845796,0.001542607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007700942,"about_ca_system_score_gemma":0.0007915556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005739738,"about_ca_topic_score_gemma":0.001651129,"domain_scores_codex":[0.9998214,0.00002794989,0.00002223638,0.00003020582,0.00007209269,0.00002610282],"domain_scores_gemma":[0.9997239,0.0001294563,0.00003936622,0.00000949524,0.00006932971,0.0000284667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000153109,0.0001016903,0.0001393373,0.00776807,0.00007337405,0.0003655592,0.00003843387,0.0006207653,0.00336497,0.004495355,0.04374641,0.939133],"study_design_scores_gemma":[0.00005123178,0.00009660972,0.0004400207,0.001368161,0.0001196168,0.001545358,0.00003861178,0.0002307228,0.001128179,0.002686284,0.9922747,0.00002052255],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001153485,0.9982622,0.0002533729,0.0003241573,0.0002696933,0.000004025847,0.00001391748,0.00000991335,0.0007473518],"genre_scores_gemma":[0.001037674,0.9972823,0.0003252772,0.0002792426,0.000372728,0.000007854254,0.0000329861,0.000002811935,0.0006591975],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002437072,"threshold_uncertainty_score":0.008152843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04034253451407801,"score_gpt":0.3398296765474751,"score_spread":0.2994871420333971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}