{"id":"W2006257070","doi":"10.1038/onc.2009.424","title":"The tumor suppressor ING3 is degraded by SCFSkp2-mediated ubiquitin–proteasome system","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"National Cancer Institute; University of British Columbia; Terry Fox Foundation; Canadian Institutes of Health Research; Cancer Research Society; Canadian Dermatology Foundation; Michael Smith Health Research BC; Dermatology Foundation","keywords":"Biology; Suppressor; Proteasome; Ubiquitin; Carcinogenesis; Tumor suppressor gene; Cancer research; Cell biology; Ubiquitin ligase; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003941636,0.0002917513,0.0002356445,0.00003090548,0.000372149,0.0000998047,0.0005183806,0.0001952508,0.00004266469],"category_scores_gemma":[0.0001300065,0.0002204517,0.0001552483,0.0001541158,0.00009978587,0.000005836039,0.00009967212,0.0001733734,0.000128338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004233496,"about_ca_system_score_gemma":0.000111611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001592753,"about_ca_topic_score_gemma":0.000006067899,"domain_scores_codex":[0.9981345,0.0001516652,0.0003527672,0.0004978592,0.0002859196,0.0005773092],"domain_scores_gemma":[0.9988198,0.00003453049,0.0001746539,0.0006498228,0.0001147241,0.0002064149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001267957,0.00005583918,0.00007920162,0.00002280812,0.00004244508,0.00001192502,0.00004920773,8.36558e-7,0.9704188,0.0001546162,0.02624517,0.002792381],"study_design_scores_gemma":[0.0005703476,0.0003262802,0.0001014692,0.00002532161,0.00001754233,0.000040115,0.00009725494,0.00004874005,0.7653633,0.00004233783,0.2331223,0.0002450106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815693,0.006919184,0.0002276012,0.001808857,0.0002891024,0.0008537081,0.0004380045,0.0001201913,0.007773979],"genre_scores_gemma":[0.9948123,0.0001422251,0.0002514408,0.001812035,0.0004718643,0.0001118532,0.0003134822,0.00004018663,0.002044573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2068771,"threshold_uncertainty_score":0.898976,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008827338543823152,"score_gpt":0.2310816266210194,"score_spread":0.2222542880771963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}