{"id":"W2006257070","doi":"10.1038/onc.2009.424","title":"The tumor suppressor ING3 is degraded by SCFSkp2-mediated ubiquitin–proteasome system","year":2009,"lang":"en","type":"article","venue":"Oncogene","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver Coastal Health; Vancouver Coastal Health Research Institute; University of British Columbia","funders":"National Cancer Institute; University of British Columbia; Terry Fox Foundation; Canadian Institutes of Health Research; Cancer Research Society; Canadian Dermatology Foundation; Michael Smith Health Research BC; Dermatology Foundation","keywords":"Biology; Suppressor; Proteasome; Ubiquitin; Carcinogenesis; Tumor suppressor gene; Cancer research; Cell biology; Ubiquitin ligase; Genetics; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000159266,0.0006200859,0.0002726907,0.0003996243,0.0004043592,0.000658587,0.000249673,0.0002510285,0.001095382],"category_scores_gemma":[0.000130843,0.0002021832,0.0003507399,0.0003336692,0.0001931102,0.0002785893,0.0003309664,0.0005042119,0.0008885708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000994197,"about_ca_system_score_gemma":0.0003769396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001503058,"about_ca_topic_score_gemma":0.001940325,"domain_scores_codex":[0.999887,0.000009258687,0.000007321452,0.0000225068,0.00003411417,0.00003990203],"domain_scores_gemma":[0.9999028,0.000006824354,0.0000326183,0.0000132579,0.00001788031,0.00002650087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000209987,0.00001800577,0.0007980814,0.00004238435,0.00001565576,0.0002674742,0.00001264084,0.0001364789,0.9950475,0.0003171265,0.0003368748,0.002797857],"study_design_scores_gemma":[0.0000141419,0.0000371771,0.006412582,0.000003678866,0.00001914036,0.0007319807,0.0000289426,0.001601142,0.9859201,0.0001813894,0.005043624,0.000006161305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870826,0.004200709,0.00465537,0.0002662013,0.00006413188,0.00001471286,0.0008146646,0.000486603,0.002415001],"genre_scores_gemma":[0.992911,0.0009009576,0.001152634,0.00004260636,0.0000103091,0.000007502461,0.001374634,0.00003770303,0.003562476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503058,"threshold_uncertainty_score":0.007213414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008827338543823152,"score_gpt":0.2310816266210194,"score_spread":0.2222542880771963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}