{"id":"W2006269322","doi":"10.1371/journal.pone.0084134","title":"Myxoma Virus Oncolytic Efficiency Can Be Enhanced Through Chemical or Genetic Disruption of the Actin Cytoskeleton","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Cancer Research UK; University of Alberta; Alberta Cancer Foundation; Cancer Research Institute","keywords":"Oncolytic virus; Myxoma virus; Actin; Cytoskeleton; Actin cytoskeleton; Cell biology; Myxoma; Biology; Virus; Virology; Genetics; Medicine; Cell; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570903,0.0002973358,0.0002011971,0.0001815153,0.00008829762,0.0003485062,0.0001329211,0.0002904739,0.0006856184],"category_scores_gemma":[0.0001076437,0.0001144546,0.0002269988,0.00008402095,0.0001492321,0.000187621,0.0002271228,0.0004547984,0.0002025239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844264,"about_ca_system_score_gemma":0.000105713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002616048,"about_ca_topic_score_gemma":0.0003767043,"domain_scores_codex":[0.9998738,0.00001972785,0.00001431597,0.00002343687,0.00003787506,0.00003085682],"domain_scores_gemma":[0.999927,0.00002097772,0.00002213775,0.000009829426,0.000006752922,0.00001314712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002045646,0.00001217457,0.00004356863,0.0000151551,0.000001684417,0.00000916994,0.000006034747,0.00002347032,0.999186,0.00007662134,0.00001305594,0.0005925699],"study_design_scores_gemma":[0.000006693363,0.0001951267,0.0009886005,0.000004103948,0.00000729926,0.00009457342,0.000005590439,0.0005249133,0.9963686,0.00002571222,0.001776741,0.000002060261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903821,0.001692307,0.00551862,0.00007144285,0.00002947049,0.00005137308,0.0002096792,0.0001059591,0.00193896],"genre_scores_gemma":[0.9919826,0.0008579429,0.004447909,0.0000255068,0.000008098576,0.00004189045,0.0003323601,0.00002879366,0.002274869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006856184,"threshold_uncertainty_score":0.002293646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03702812778782287,"score_gpt":0.2915002186489865,"score_spread":0.2544720908611636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}